INT29762

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Context Info
Confidence 0.21
First Reported 1988
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (P4hb) endoplasmic reticulum (P4hb) plasma membrane (P4hb)
Anatomy Link Frequency
neuronal 1
P4hb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 96.08 Very High Very High Very High
noradrenaline 6 95.04 Very High Very High Very High
agonist 4 85.28 High High
Clonidine 1 84.56 Quite High
Dopamine 35 84.32 Quite High
Kinase C 4 81.64 Quite High
adenocard 5 79.20 Quite High
Hippocampus 8 75.00 Quite High
Morphine 4 53.76 Quite High
nMDA receptor 3 6.96 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 6 98.60 Very High Very High Very High
Parkinson's Disease 1 96.90 Very High Very High Very High
Dementia 2 96.56 Very High Very High Very High
Brain Disease 2 94.72 High High
Death 5 93.90 High High
Stress 14 92.76 High High
Schizophrenia 220 89.52 High High
Thyroid Disease 6 63.28 Quite High
Psychosis 7 56.88 Quite High
Chronic Obstructive Pulmonary Disease 22 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of PDiBu was not significantly reduced by nifedipine (1 microM), but was proportionally less in the presence of an alpha 2-adrenoceptor antagonist, yohimbine.
Neg (not) Negative_regulation (reduced) of PDiBu associated with antagonist
1) Confidence 0.21 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2842695 Disease Relevance 0 Pain Relevance 0.75
PDI provides neuroprotection by facilitating protein folding and preventing misfolding.241 PDI is believed to prevent nitrosative stress that leads to protein misfolding and neuronal cell death that causes degenerative brain disorders.241 Several neurodegenerative disorders are linked to protein misfolding including dementia with Lewy bodies.242 BPA binds to PDI and inhibits its activity.243 The deactivation of PDI may be responsible for various effects of BPA,243 and one could speculate that inhibition of PDI by BPA would increase the risk of neurodegenerative disorders.


Negative_regulation (inhibition) of PDI in neuronal associated with parkinson's disease, stress, dementia, brain disease, neurodegenerative disease and death
2) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.36 Pain Relevance 0.11
Although both Ppl and Pdi indices of inspiratory work decreased after IPAP and CPAP, only the reduction in Pdi work achieved statistical significance.
Negative_regulation (reduction) of Pdi
3) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0 Pain Relevance 0
Other studies have similarly shown a significant reduction in tidal Pdi swings but not esophageal pressure swings with CPAP in patients with airflow limitation [6,10].
Negative_regulation (reduction) of Pdi
4) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.05 Pain Relevance 0

General Comments

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