INT297621

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RLN3)
Anatomy Link Frequency
B-cells 1
RLN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
pruritus 2 36.24 Quite Low
abdominal pain 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 18 94.16 High High
Anorexia 8 93.04 High High
Bartter Syndrome 2 92.08 High High
Vomiting 58 91.32 High High
Diarrhoea 12 90.68 High High
Lymphatic System Cancer 30 84.48 Quite High
Myelodysplastic Syndromes 30 78.72 Quite High
Volume Depletion And Dehydration 2 78.60 Quite High
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 78.36 Quite High
Myeloid Leukemia 36 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H3 and H2B acetylation increase was significant in B-cells and blasts.
Positive_regulation (increase) of H3 in B-cells
1) Confidence 0.05 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.77 Pain Relevance 0
Pharmacodynamic (PD) evaluations confirmed inhibition of HDAC activity and induction of acetylation of H3 histones in peripheral WBCs from patients by MGCD0103.
Positive_regulation (induction) of H3
2) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.02 Pain Relevance 0

General Comments

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