INT297628

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF275) intracellular (ZNF275) DNA binding (ZNF275)
ZNF275 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 94 97.32 Very High Very High Very High
Myeloid Leukemia 36 96.00 Very High Very High Very High
Hypocalcemia 2 87.00 High High
Hypoalbuminemia 4 86.24 High High
Vomiting 58 85.56 High High
Anorexia 8 84.84 Quite High
Fatigue 36 84.44 Quite High
Non-small-cell Lung Cancer 16 84.24 Quite High
Neurologic Gait Disorders 2 82.32 Quite High
Toxicity 22 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-clinical studies suggested that combining inhibitors of DNA methyltransferase (DNMT), 5-azacitidine (AZA), with inhibitors of HDAC, SNDX-275, synergistically induced re-expression of epigenetically-silenced tumor suppressor genes and had anti-tumor effect.
Negative_regulation (inhibitors) of SNDX-275 associated with cancer
1) Confidence 0.00 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.62 Pain Relevance 0
Pre-clinical studies suggested that combining inhibitors of DNA methyltransferase (DNMT), 5-azacitidine (AZA), with inhibitors of HDAC, SNDX-275, synergistically induced re-expression of epigenetically-silenced tumor suppressor genes and had anti-tumor effect.
Negative_regulation (inhibitors) of SNDX-275 associated with cancer
2) Confidence 0.00 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.58 Pain Relevance 0

General Comments

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