INT29763

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 1996
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
neurons 1
hippocampus 1
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 17 100.00 Very High Very High Very High
agonist 3 99.96 Very High Very High Very High
Hippocampus 3 99.42 Very High Very High Very High
noradrenaline 6 98.76 Very High Very High Very High
Kinase C 4 98.06 Very High Very High Very High
antinociception 5 96.56 Very High Very High Very High
antagonist 5 87.84 High High
addiction 1 85.04 High High
Clonidine 1 69.76 Quite High
nMDA receptor 1 65.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both antinociception and locomotor stimulation appear to be dependent on activation of adenosine A1 receptors, as effects of 3,7-dimethyl-1-propargylxanthine are observed only at a dose which blocks adenosine A1 receptors in addition to A2 receptors.
Negative_regulation (blocks) of adenosine A1 associated with antinociception and adenocard
1) Confidence 0.42 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8867096 Disease Relevance 0 Pain Relevance 0.55
Protein kinase C activation increases noradrenaline release from the rat hippocampus and modifies the inhibitory effect of alpha 2-adrenoceptor and adenosine A1-receptor agonists.
Negative_regulation (effect) of A1-receptor in hippocampus associated with adenocard, kinase c, agonist, noradrenaline and hippocampus
2) Confidence 0.11 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2842695 Disease Relevance 0 Pain Relevance 0.81
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: pre- and postsynaptic components.
Negative_regulation (suppression) of A1 receptor in neurons associated with adenocard
3) Confidence 0.11 Published 1993 Journal Neuroscience Section Title Doc Link 8309525 Disease Relevance 0 Pain Relevance 0.28

General Comments

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