INT297679

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 8.02
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
Stromal cell 2
hilus 2
epithelial cells 2
hippocampus 2
granule cell 2
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 148 100.00 Very High Very High Very High
Hippocampus 245 99.68 Very High Very High Very High
cytokine 78 95.60 Very High Very High Very High
Inflammation 29 92.80 High High
Multiple sclerosis 14 75.00 Quite High
Spinal cord 14 73.40 Quite High
cerebral cortex 7 62.60 Quite High
GABAergic 7 60.56 Quite High
Central nervous system 49 58.96 Quite High
imagery 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 308 99.98 Very High Very High Very High
Adhesions 140 99.68 Very High Very High Very High
Status Epilepticus 133 99.56 Very High Very High Very High
Colon Cancer 100 99.52 Very High Very High Very High
Apoptosis 209 99.04 Very High Very High Very High
Metastasis 100 98.24 Very High Very High Very High
INFLAMMATION 29 92.80 High High
Repression 20 89.88 High High
Carcinoma 100 88.96 High High
Gliosis 7 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most pronounced increase in CXCL12 expression over basal levels was observed in the SGZ and hilus of the DG (arrows, Figure 4D).
Positive_regulation (increase) of Gene_expression (expression) of CXCL12 in hilus
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.61 Pain Relevance 0.11
These data demonstrate that seizures augment CXCL12 expression in the DG.


Positive_regulation (augment) of Gene_expression (expression) of CXCL12 associated with convulsion
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.63 Pain Relevance 0.10
Our data corroborate earlier studies demonstrating that CXCL12 expression is increased following status epilepticus, but this increase may be transient without spontaneous recurrent seizures.
Positive_regulation (increased) of Gene_expression (expression) of CXCL12 associated with convulsion and status epilepticus
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 1.16 Pain Relevance 0.17
This hypothesis was supported by our finding that seizures upregulated CXCL12 expression in the hippocampus DG.
Positive_regulation (upregulated) of Gene_expression (expression) of CXCL12 in hippocampus associated with convulsion and hippocampus
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.50 Pain Relevance 0.40
At the time of injection of ESNPs into the DG, post-seizure expression of CXCL12 was elevated in the DG and CA3, compared to control mice that did not experience prior seizures, based upon immunohistochemical analysis (Figure 4A, B).
Positive_regulation (elevated) of Gene_expression (expression) of CXCL12 associated with convulsion
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.58 Pain Relevance 0.13
To determine whether CXCL12-induced migration is mediated via CXCR4 receptors, we blocked CXCR4 receptors with a small pharmacological inhibitor, AMD3100 [40].
Spec (whether) Positive_regulation (mediated) of Spec (whether) Gene_expression (migration) of CXCL12-induced
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.09
Our studies suggest that at least part of the mechanism for guiding new cells to their final position in the granule cell layer is the expression of CXCL12, as ESNPs show a directional migration toward a source of this chemokine in vitro, and their migration is truncated in vivo after infusion with AMD3100, an inhibitor of CXCR4.
Positive_regulation (truncated) of Gene_expression (expression) of CXCL12 in granule cell associated with chemokine
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.53 Pain Relevance 0.33
Together, these data suggest constitutive CXCL12 expression is a novel extracellular regulator of anoikis by inducing Bim-mediated intrinsic apoptotic pathway and inhibiting metastasis.


Positive_regulation (inducing) of Gene_expression (expression) of CXCL12 associated with apoptosis and metastasis
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.87 Pain Relevance 0.03
Autocrine CXCL12 expression sensitizes epithelial cells to anoikis
Positive_regulation (Autocrine) of Gene_expression (expression) of CXCL12 in epithelial cells
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.32 Pain Relevance 0.07
The loss of adhesion coincides with increased levels of secreted CXCL12 over that same time span, from not detectable at day 0 to a maximum after 4-days in culture (data not shown).
Positive_regulation (increased) of Gene_expression (levels) of CXCL12 associated with adhesions
10) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.10 Pain Relevance 0.08
Our earlier studies have shown that constitutive expression of the chemokine CXCL12 induces anoikis in colorectal carcinoma cells [13].
Positive_regulation (induces) of Gene_expression (expression) of CXCL12 associated with chemokine and colon cancer
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.81 Pain Relevance 0.05
Furthermore, the injection of the cells prevented an increase in SDF-1 (Stromal cell-Derived Factor-1) a potent B chemoattractor, which is produced by several cell types [21], thus indicating that many different immune functions can be slowed down or controlled by injection of hAFSC.
Positive_regulation (increase) of Gene_expression (produced) of SDF-1 in Stromal cell
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.92 Pain Relevance 0.46

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