INT297707

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.76
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cbr1) plasma membrane (Cbr1) nucleus (Cbr1)
cytoplasm (Cbr1)
Anatomy Link Frequency
neurons 2
gastrocnemius 2
apoptotic cell 2
Cbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 92 87.68 High High
dexamethasone 4 69.04 Quite High
Action potential 1 24.00 Low Low
Spinal cord 8 10.52 Low Low
imagery 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Pyramidal cell 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 41 99.62 Very High Very High Very High
Apoptosis 143 99.40 Very High Very High Very High
Disease 68 98.72 Very High Very High Very High
Disease Progression 44 98.24 Very High Very High Very High
Stress 216 96.08 Very High Very High Very High
Motor Neuron Diseases 64 91.32 High High
INFLAMMATION 92 87.68 High High
Lifespan 48 65.40 Quite High
Aging 16 42.08 Quite Low
Body Weight 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that a small percentage of CR neurons survive from P3 into adulthood (Figure 4), confirming the notion that CR neurons must play additional roles besides their known involvement in neuronal migration.
Positive_regulation (percentage) of Gene_expression (neurons) of CR in neurons
1) Confidence 0.13 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0
In the white gastrocnemius, CR lowered PC (30%, P?
Positive_regulation (lowered) of Gene_expression (lowered) of CR in gastrocnemius
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
Activation of this proapoptotic protein may potentially trigger apoptotic cell death and is a possible explanation of why CR hastened the clinical onset of disease and disease progression in G93A mice
Spec (possible) Positive_regulation (why) of Spec (possible) Gene_expression (explanation) of CR in apoptotic cell associated with disease, apoptosis, disease progression and death
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.77 Pain Relevance 0.03
The authors suggest that severe CR has a greater effect in reducing lipid peroxidation earlier in life [36], hence the higher peroxidative potential in the young slightly restricted mice.
Positive_regulation (severe) of Gene_expression (severe) of CR
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
Contrarily, CR females upregulated UCP3, a marker of mitochondrial energetics, which is activated in response to enhanced oxidative stress [21].
Positive_regulation (upregulated) of Gene_expression (females) of CR associated with stress
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.99 Pain Relevance 0.08

General Comments

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