INT297709

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.67
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp3) mitochondrion (Ucp3) transmembrane transport (Ucp3)
Anatomy Link Frequency
muscle 4
skeletal muscle 2
Ucp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 48 100.00 Very High Very High Very High
Inflammation 47 91.08 High High
Eae 14 80.64 Quite High
Etanercept 4 68.52 Quite High
antagonist 13 54.60 Quite High
agonist 16 49.64 Quite Low
cINOD 1 36.44 Quite Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Cannabinoid 8 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 190 100.00 Very High Very High Very High
Cancer 150 100.00 Very High Very High Very High
Frailty 18 100.00 Very High Very High Very High
Targeted Disruption 83 99.88 Very High Very High Very High
Obesity 379 99.84 Very High Very High Very High
Body Weight 125 95.64 Very High Very High Very High
INFLAMMATION 52 91.08 High High
Stress 56 88.04 High High
Syndrome 18 85.20 High High
Disorder Of Lipid Metabolism 16 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is in line with studies showing an association of CR with increased levels of UCP3.
Positive_regulation (increased) of Gene_expression (levels) of UCP3
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.50 Pain Relevance 0
Transgenic mice overexpressing UCP3 in their skeletal muscle exhibit increased FA oxidation and are resistant to diet-induced obesity.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of UCP3 in skeletal muscle associated with targeted disruption and obesity
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.81 Pain Relevance 0
The observed increase in the expression of Ucp-1 and Ucp-3 in BAT of iNOS-deficient mice in the present study supports this mechanism.
Positive_regulation (increase) of Gene_expression (expression) of Ucp-3 associated with obesity
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.85 Pain Relevance 0.13
Moreover, ablation of iNOS increases Ucp-1 and Ucp-3 expression, which, in turn, may increase the rate of ?
Positive_regulation (increases) of Gene_expression (expression) of Ucp-3
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.95 Pain Relevance 0.03
Interleukin-15 has been reported to be an anabolic factor for skeletal muscle.49 This cytokine is able to decrease protein degradation, decrease the rate of DNA fragmentation and increase UCP3 expression in skeletal muscle, these being the most important trends associated with muscle wasting during cancer cachexia.50,51 In vitro experiments carried out using both isolated incubated muscle and muscle cells in culture corroborate the in vivo observations indicating a direct action of the cytokine upon skeletal muscle.52 Although no clinical data are available, treatment of cachectic experimental animals with IL-15 leads to an improvement of muscle mass and performance.50


Other therapeutic approaches

Anabolic steroids

Positive_regulation (upon) of Gene_expression (expression) of UCP3 in muscle associated with appetite loss, cancer, frailty and cytokine
5) Confidence 0.13 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 0.89 Pain Relevance 0.56
Interleukin-15 has been reported to be an anabolic factor for skeletal muscle.49 This cytokine is able to decrease protein degradation, decrease the rate of DNA fragmentation and increase UCP3 expression in skeletal muscle, these being the most important trends associated with muscle wasting during cancer cachexia.50,51 In vitro experiments carried out using both isolated incubated muscle and muscle cells in culture corroborate the in vivo observations indicating a direct action of the cytokine upon skeletal muscle.52 Although no clinical data are available, treatment of cachectic experimental animals with IL-15 leads to an improvement of muscle mass and performance.50


Other therapeutic approaches

Anabolic steroids

Positive_regulation (increase) of Gene_expression (expression) of UCP3 in muscle associated with appetite loss, cancer, frailty and cytokine
6) Confidence 0.13 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 0.67 Pain Relevance 0.56

General Comments

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