INT297715

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.59
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cbr1) plasma membrane (Cbr1) nucleus (Cbr1)
cytoplasm (Cbr1)
Anatomy Link Frequency
skeletal muscle 1
Cbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 92 95.76 Very High Very High Very High
cytokine 8 89.24 High High
Hippocampus 4 59.76 Quite High
cerebral cortex 4 58.72 Quite High
Substantia nigra 4 57.12 Quite High
ischemia 4 21.12 Low Low
Spinal cord 8 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 36 98.08 Very High Very High Very High
Stress 216 96.64 Very High Very High Very High
INFLAMMATION 92 95.76 Very High Very High Very High
Apoptosis 136 90.60 High High
Disease 68 81.28 Quite High
Obesity 8 76.24 Quite High
Lifespan 48 63.56 Quite High
Stroke 4 61.76 Quite High
Hypertension 4 59.60 Quite High
Motor Neuron Diseases 64 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the novel aspects of this study is the CR-associated increase in MDA and TNF-?.
Positive_regulation (increase) of CR
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.36 Pain Relevance 0.39
In our study, MDA and PC move in opposing directions as a consequence of CR, which is a finding that proposes some important questions, including whether an increase in PC is concordant with an increase in MDA.
Positive_regulation (consequence) of CR
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.41 Pain Relevance 0
We have shown that UCP3 protein content is elevated in CR female skeletal muscle.
Positive_regulation (elevated) of CR in skeletal muscle
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.51 Pain Relevance 0
It is possible that decreases in mitochondrial oxidant production, as a result of long-term CR, failed to balance the increase in free radical production from the mutant enzyme found mainly in the cytosol, leading to a net increase in oxidative stress [9].
Positive_regulation (result) of CR associated with stress
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.31 Pain Relevance 0

General Comments

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