INT297724

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Context Info
Confidence 0.63
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.67
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp3) mitochondrion (Ucp3) transmembrane transport (Ucp3)
Anatomy Link Frequency
skeletal muscle 2
muscle 1
Ucp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 38 98.12 Very High Very High Very High
Inflammation 140 90.72 High High
Eae 42 80.64 Quite High
Etanercept 2 68.16 Quite High
antagonist 8 54.24 Quite High
agonist 21 49.64 Quite Low
cINOD 1 36.44 Quite Low
Bile 5 23.76 Low Low
tolerance 19 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 253 99.88 Very High Very High Very High
Obesity 869 99.84 Very High Very High Very High
Disease 84 98.52 Very High Very High Very High
Frailty 9 97.00 Very High Very High Very High
Cancer 84 96.12 Very High Very High Very High
Appetite Loss 97 95.84 Very High Very High Very High
Body Weight 241 95.64 Very High Very High Very High
Stress 229 95.28 Very High Very High Very High
INFLAMMATION 147 90.72 High High
Apoptosis 143 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UCP3 gene expression is up-regulated before the onset of disease (90 d) in skeletal muscle of G86R mice, as well as in SALS patients [54].
Gene_expression (expression) of UCP3 gene in skeletal muscle associated with disease
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.56 Pain Relevance 0
This finding is in line with studies showing an association of CR with increased levels of UCP3.
Gene_expression (levels) of UCP3
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.50 Pain Relevance 0
However, unlike the CR females, UCP3 protein content was not significantly higher in CR vs.
Gene_expression (content) of UCP3 protein
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
UCP3 was higher in CR vs.
Gene_expression (higher) of UCP3
4) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827549 Disease Relevance 0.89 Pain Relevance 0.08
As shown in Fig. 3, the gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Gene_expression (expression) of Ucp-3 associated with obesity
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.57 Pain Relevance 0
Immunohistological analyses showed a high expression of Ucp-1 and Ucp-3 in BAT in all experimental groups.
Gene_expression (expression) of Ucp-3 associated with obesity
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.44 Pain Relevance 0
Transgenic mice overexpressing UCP3 in their skeletal muscle exhibit increased FA oxidation and are resistant to diet-induced obesity.
Gene_expression (overexpressing) of UCP3 in skeletal muscle associated with targeted disruption and obesity
7) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.81 Pain Relevance 0
Sections were incubated overnight at 4°C with rabbit monoclonal anti-Ucp-1 or Ucp-3 antibodies (Abcam) diluted 1?
Gene_expression (antibodies) of Ucp-3
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.08 Pain Relevance 0
As shown in Fig. 3, the gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Gene_expression (levels) of Ucp-3 associated with obesity
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.56 Pain Relevance 0
The observed increase in the expression of Ucp-1 and Ucp-3 in BAT of iNOS-deficient mice in the present study supports this mechanism.
Gene_expression (expression) of Ucp-3 associated with obesity
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.84 Pain Relevance 0.13
Moreover, ablation of iNOS increases Ucp-1 and Ucp-3 expression, which, in turn, may increase the rate of ?
Gene_expression (expression) of Ucp-3
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.94 Pain Relevance 0.03
UCP3 was found to be necessary for fasting-induced increase in fatty acid oxidation rate and capacity through mitigation of mitochondrial oxidative stress [30].
Gene_expression (necessary) of UCP3 associated with stress
12) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.80 Pain Relevance 0
Interleukin-15 has been reported to be an anabolic factor for skeletal muscle.49 This cytokine is able to decrease protein degradation, decrease the rate of DNA fragmentation and increase UCP3 expression in skeletal muscle, these being the most important trends associated with muscle wasting during cancer cachexia.50,51 In vitro experiments carried out using both isolated incubated muscle and muscle cells in culture corroborate the in vivo observations indicating a direct action of the cytokine upon skeletal muscle.52 Although no clinical data are available, treatment of cachectic experimental animals with IL-15 leads to an improvement of muscle mass and performance.50


Other therapeutic approaches

Anabolic steroids

Gene_expression (expression) of UCP3 in muscle associated with appetite loss, cancer, frailty and cytokine
13) Confidence 0.20 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 0.67 Pain Relevance 0.56

General Comments

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