INT297726

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 7.68
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cbr1) plasma membrane (Cbr1) nucleus (Cbr1)
cytoplasm (Cbr1)
Anatomy Link Frequency
neurons 12
gastrocnemius 2
apoptotic cell 1
Cbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 103 99.64 Very High Very High Very High
Pyramidal cell 60 95.28 Very High Very High Very High
gABA 24 90.00 High High
Inflammation 367 87.68 High High
dexamethasone 15 77.68 Quite High
imagery 156 76.08 Quite High
ischemia 15 49.08 Quite Low
Action potential 12 38.52 Quite Low
Substantia nigra 15 31.40 Quite Low
Spinal cord 30 30.88 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 43 99.82 Very High Very High Very High
Stress 811 99.62 Very High Very High Very High
Death 195 99.62 Very High Very High Very High
Apoptosis 594 99.40 Very High Very High Very High
Disease 255 98.72 Very High Very High Very High
Disease Progression 165 98.24 Very High Very High Very High
Motor Neuron Diseases 240 91.32 High High
Aging 60 88.00 High High
INFLAMMATION 367 87.68 High High
Lifespan 180 74.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is important to note that reelin is not an ideal marker of CR neurons because, although all CR neurons express reelin, reelin is also expressed in many other cortical cells, not just in L1 (Alcantara et al., 1998; Meyer et al., 1998).
Gene_expression (neurons) of CR in neurons
1) Confidence 0.20 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.16
We also demonstrate that a small percentage of CR neurons survive from P3 into adulthood (Figure 4), confirming the notion that CR neurons must play additional roles besides their known involvement in neuronal migration.
Gene_expression (neurons) of CR in neurons
2) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0
We find that the overwhelming majority of CR neurons present around the time of birth die by apoptosis during the second postnatal week, and very few (<3%) survive to adulthood.
Gene_expression (neurons) of CR in neurons associated with apoptosis
3) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0.47 Pain Relevance 0.04
Importantly, during the first two postnatal weeks the vast majority (>97%) of reelin+ cells that had the unique CR morphology were GFP+, suggesting that in the cortical regions we imaged, practically all CR neurons express Ebf2.
Gene_expression (neurons) of CR in neurons
4) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.04
We also demonstrate that a small percentage of CR neurons survive from P3 into adulthood (Figure 4), confirming the notion that CR neurons must play additional roles besides their known involvement in neuronal migration.
Gene_expression (neurons) of CR in neurons
5) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0
CR neurons in Ebf2 mice were widely distributed in all cortical regions that we examined, including motor, somatosensory and visual cortices (not shown).
Gene_expression (neurons) of CR in neurons
6) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.04
cells with a CR morphology between P6 and P13, which corresponds to the time of rapid disappearance of Ebf2-expressing CR neurons.
Gene_expression (neurons) of CR in neurons
7) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0.07 Pain Relevance 0
In that sense, the identification of a mouse line that expresses GFP in all postnatal CR neurons is noteworthy, as future studies using these mice (e.g., gene expression profiling) may help to determine whether a subset of CR cells manifest important roles as functional neurons integrated in neocortical circuits.
Gene_expression (neurons) of CR in neurons
8) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0.24 Pain Relevance 0.15
The best understood function of CR neurons is in cortical lamination.
Gene_expression (neurons) of CR in neurons
9) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0.07 Pain Relevance 0
It is important to note that reelin is not an ideal marker of CR neurons because, although all CR neurons express reelin, reelin is also expressed in many other cortical cells, not just in L1 (Alcantara et al., 1998; Meyer et al., 1998).
Gene_expression (neurons) of CR in neurons
10) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.17
Importantly, during the first two postnatal weeks the vast majority (>97%) of reelin+ cells that had the unique CR morphology were GFP+, suggesting that in the cortical regions we imaged, practically all CR neurons express Ebf2.
Gene_expression (express) of CR in neurons
11) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.04
Importantly, during the first two postnatal weeks the vast majority (>97%) of reelin+ cells that had the unique CR morphology were GFP+, suggesting that in the cortical regions we imaged, practically all CR neurons express Ebf2.
Gene_expression (practically) of CR in neurons
12) Confidence 0.18 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.04
Hence, in a subset of 64 mice (16 each for AL females, AL males, CR females and CR males), voluntary activity was recorded at age 72–89 d using mice activity wheels with living chambers (Single Activity Wheel Chamber Systerm Model 80820, Lafayette Instrument, Lafayette, IN).
Gene_expression (females) of CR
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.09 Pain Relevance 0
CR male mice had significantly less Hsp70 protein content than CR females, indicating that they are less protected from cell stress.
Gene_expression (females) of CR associated with stress
14) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.10 Pain Relevance 0.06
The protein content of a molecular chaperone, Hsp70, generally up-regulated in response to cell stress, was reduced as a result of CR.
Gene_expression (result) of CR associated with stress
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.73 Pain Relevance 0.12
0.996; CR females, r?
Gene_expression (females) of CR
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.32 Pain Relevance 0
For the CR group, PaGE was recorded before mice were provided with food.


Gene_expression (group) of CR
17) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.09 Pain Relevance 0
0.984; CR males, r?
Gene_expression (males) of CR
18) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.26 Pain Relevance 0
0.997; CR males, r?
Gene_expression (males) of CR
19) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.32 Pain Relevance 0
Activation of this proapoptotic protein may potentially trigger apoptotic cell death and is a possible explanation of why CR hastened the clinical onset of disease and disease progression in G93A mice
Spec (possible) Gene_expression (explanation) of CR in apoptotic cell associated with disease, apoptosis, disease progression and death
20) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.77 Pain Relevance 0.03

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