INT297728

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.45
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
motor neurons 1
microglia 1
Sod1m (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 37 92.40 High High
Spinal cord 4 77.68 Quite High
Inflammatory response 14 58.72 Quite High
ischemia 1 26.00 Quite Low
Substantia nigra 9 8.32 Low Low
cerebral cortex 1 7.48 Low Low
Hippocampus 11 6.80 Low Low
Central nervous system 42 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 56 98.42 Very High Very High Very High
Drug Induced Neurotoxicity 12 98.28 Very High Very High Very High
Toxicity 8 98.04 Very High Very High Very High
Disease 127 95.40 Very High Very High Very High
INFLAMMATION 51 92.40 High High
Targeted Disruption 19 91.00 High High
Motor Neuron Diseases 38 88.88 High High
Apoptosis 44 87.28 High High
Death 27 86.08 High High
Disease Progression 21 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results coincide with the previous studies mentioned, which illustrate the reduced ability of motor neurons to upregulate Hsp70 under stress conditions [71], and the inhibition of Hsp70's antiapoptotic role through its binding with mSOD1 [79].
mSOD1 Binding (binding) of in motor neurons associated with stress
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.15 Pain Relevance 0.13
Zhao et al. [116] have demonstrated that mSOD1 binds to CD14, which has a role in the activation and toxicity of microglia treated with extracellular mSOD1.
mSOD1 Binding (binds) of in microglia associated with toxicity
2) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.07 Pain Relevance 0.03
One proposed mechanism for pathogenesis is the aberrant oligomerization of mSOD1 proteins in beta-sheet form, that can be stained by thioflavin S [113].
mSOD1 Binding (oligomerization) of
3) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.23 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox