INT297738

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.83
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cbr1, Ifih1) nucleus (Cbr1, Ifih1) intracellular (Ifih1)
helicase activity (Ifih1) DNA binding (Ifih1) oxidoreductase activity (Cbr1)
Anatomy Link Frequency
liver 1
gastrocnemius 1
Cbr1 (Mus musculus)
Ifih1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 69 96.32 Very High Very High Very High
cytokine 6 89.24 High High
Hippocampus 3 60.32 Quite High
cerebral cortex 3 59.28 Quite High
Substantia nigra 3 57.68 Quite High
ischemia 3 21.68 Low Low
Spinal cord 6 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 27 98.08 Very High Very High Very High
Stress 162 97.20 Very High Very High Very High
INFLAMMATION 69 96.32 Very High Very High Very High
Apoptosis 102 90.60 High High
Disease 51 73.40 Quite High
Lifespan 36 63.56 Quite High
Mitochondrial Myopathies 3 59.56 Quite High
Motor Neuron Diseases 48 57.84 Quite High
Cv Unclassified Under Development 3 21.68 Low Low
Injury 3 20.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, CR (2 mo; 70% of AL) increased MDA by 3-fold in the liver and by 50% in the heart of male Sprague-Dawley rats, an animal model with elevated basal levels of stress-induced corticosterone, vs.
CR Positive_regulation (increased) of MDA in liver associated with stress
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.15 Pain Relevance 0
In the present study, we determined that CR significantly increased MDA in both the red and white gastrocnemius.
CR Positive_regulation (increased) of MDA in gastrocnemius
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.31 Pain Relevance 0
One of the novel aspects of this study is the CR-associated increase in MDA and TNF-?.
CR Positive_regulation (increase) of MDA
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.37 Pain Relevance 0.39

General Comments

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