INT297788

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nanos2) RNA binding (Nanos2) cytoplasm (Nanos2)
Anatomy Link Frequency
brain 2
hypothalamus 1
Nanos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 10.72 Low Low
member 8 14 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Substantia nigra 7 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Serotonin 7 5.00 Very Low Very Low Very Low
Potency 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 28 100.00 Very High Very High Very High
Male Infertility 7 100.00 Very High Very High Very High
Starvation 161 96.92 Very High Very High Very High
Sprains And Strains 7 90.44 High High
Syndrome 147 86.08 High High
Stress 77 84.56 Quite High
Hyperphagia 56 76.28 Quite High
Failure To Thrive 28 74.72 Quite High
Appetite Loss 14 73.12 Quite High
Obesity 35 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hypothalamus, Nanos2 is expressed modestly at P5 and P13.
Gene_expression (expressed) of Nanos2 in hypothalamus
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.46 Pain Relevance 0
The function of Nanos2 in brain development is unknown, as the Nanos2 knock-out mice were apparently normal except for male infertility [25], and no phenotypic abnormality was reported for Nanos2 transgenic mice, which over-express Nanos2 under the control of Oct4DeltaPE promoter, but the expression was not examined in brain [27].
Gene_expression (express) of Nanos2 in brain associated with targeted disruption and male infertility
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.58 Pain Relevance 0
But we detected transcription changes in unexpected genes, Nanos2 and Pdk4, which are increased by roughly 2-fold and 1.5-fold respectively, and Ndp, Pgpep1, Brms1l, Mett10d and Snx1, which are reduced by 25–55% (Figure 2 and Table 1).


Gene_expression (detected) of Nanos2
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.22 Pain Relevance 0
Unlike in adult rodents, expression levels of Nanos2 and Pdk4 were increased, and those of Pgpep1, Ndp, Brms1l, Mett10d, and Snx1 were decreased after neonatal deprivation.
Gene_expression (expression) of Nanos2
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827556 Disease Relevance 1.00 Pain Relevance 0
Of the 8 genes with consistently increased expression after food deprivation in both genotypes, we chose five with high to modest expression levels for qRT-PCR validation and for only two genes, Nanos2 and Pdk4, were we able to validate significantly increased expression after starvation in both WT and Snord116del hypothalami (Fig. 2A and Table 1).
Gene_expression (expression) of Nanos2 associated with starvation
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.10 Pain Relevance 0
Unlike in adult rodents, expression levels of Nanos2 and Pdk4 were increased, and those of Pgpep1, Ndp, Brms1l, Mett10d, and Snx1 were decreased after neonatal deprivation.
Gene_expression (levels) of Nanos2
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827556 Disease Relevance 1.00 Pain Relevance 0
The function of Nanos2 in brain development is unknown, as the Nanos2 knock-out mice were apparently normal except for male infertility [25], and no phenotypic abnormality was reported for Nanos2 transgenic mice, which over-express Nanos2 under the control of Oct4DeltaPE promoter, but the expression was not examined in brain [27].
Gene_expression (expression) of Nanos2 in brain associated with targeted disruption and male infertility
7) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.66 Pain Relevance 0

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