INT2978

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1977
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 76
Total Number 81
Disease Relevance 28.40
Pain Relevance 21.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 19
blood 8
plasma 6
chest 2
PGE2 2
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 3 100.00 Very High Very High Very High
aspirin 85 99.84 Very High Very High Very High
anesthesia 12 99.84 Very High Very High Very High
Inflammation 45 99.76 Very High Very High Very High
Clonidine 32 99.76 Very High Very High Very High
local anesthetic 12 99.54 Very High Very High Very High
Paracetamol 12 99.46 Very High Very High Very High
cINOD 94 99.42 Very High Very High Very High
Morphine 10 99.40 Very High Very High Very High
Angina 59 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 8 99.88 Very High Very High Very High
Coagulation Disorder 4 99.84 Very High Very High Very High
Injury 4 99.84 Very High Very High Very High
Myocardial Infarction 48 99.82 Very High Very High Very High
Hypersensitivity 25 99.80 Very High Very High Very High
INFLAMMATION 76 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 68 99.58 Very High Very High Very High
Thrombosis Related Under Development 2 99.52 Very High Very High Very High
Cv General 3 Under Development 62 99.34 Very High Very High Very High
Rheumatoid Arthritis 28 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of an antiaggregatory dose of prostacyclin (PGI2) to the incubation tube did not affect TXA2 production or the ability of transferred media to promote uterine contractions.
Gene_expression (production) of TXA2 in uterine associated with dismenorea
1) Confidence 0.77 Published 1982 Journal Biol. Reprod. Section Abstract Doc Link 7039705 Disease Relevance 0.24 Pain Relevance 0.24
Local anesthetics (LA) inhibit signaling of TXA2 receptors expressed in cell models.
Gene_expression (expressed) of TXA2
2) Confidence 0.77 Published 2000 Journal Reg Anesth Pain Med Section Abstract Doc Link 10746533 Disease Relevance 0.17 Pain Relevance 0.29
Although MK-447 alone at 1 and 10 microM had no significant effects, MK-447 at 100 microM stimulated both PGI2 and TXA2 biosynthesis, and suppressed the lipid peroxidation in the pulp tissue as estimated by thiobarbituric acid method.
Gene_expression (biosynthesis) of TXA2
3) Confidence 0.77 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3921031 Disease Relevance 0.16 Pain Relevance 0.12
Platelet aggregation and TXA2 synthesis were inhibited in a similar manner.
Gene_expression (synthesis) of TXA2 in Platelet
4) Confidence 0.73 Published 1990 Journal Drugs Section Abstract Doc Link 2081487 Disease Relevance 0.21 Pain Relevance 0.32
The effect of these NSAIDs on platelet aggregation and thromboxane A2 (TXA2) synthesis was also studied.
Gene_expression (synthesis) of TXA2 in platelet associated with cinod
5) Confidence 0.73 Published 1990 Journal Drugs Section Abstract Doc Link 2081487 Disease Relevance 0.23 Pain Relevance 0.36
The effect of these NSAIDs on platelet aggregation and thromboxane A2 (TXA2) synthesis was also studied.
Gene_expression (synthesis) of thromboxane A2 in platelet associated with cinod
6) Confidence 0.73 Published 1990 Journal Drugs Section Abstract Doc Link 2081487 Disease Relevance 0.23 Pain Relevance 0.36
Local anesthetics (LA) inhibit signaling of TXA2 receptors expressed in cell models.
Gene_expression (expressed) of TXA2 associated with local anesthetic
7) Confidence 0.69 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.60 Pain Relevance 0.39
These results show that TXA2 produced in smooth muscle cells is increased in mesenteric arteries from orchidectomized rats compared to their controls, and that this prostanoid is functionally involved in the vasoconstrictor response to clonidine only in arteries from the orchidectomized rats.
Gene_expression (produced) of TXA2 in smooth muscle cells associated with clonidine
8) Confidence 0.61 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.63
Endothelial NOS (eNOS), COX-2 and TXA2 synthase protein expression was studied by Western blot analysis.
Gene_expression (expression) of TXA2
9) Confidence 0.61 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.48
Orchidectomy failed to modify eNOS,COX-2 and TXA2 synthase expression, and increased basal and clonidine-stimulated TXB2 release.
Gene_expression (expression) of TXA2 associated with clonidine
10) Confidence 0.61 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.65
Delaying transfer of media until 10 min after addition of AA did not elicit either aggregation or contractile response, consistent with the short production interval and half-life of TXA2.
Gene_expression (production) of TXA2
11) Confidence 0.58 Published 1982 Journal Biol. Reprod. Section Abstract Doc Link 7039705 Disease Relevance 0.24 Pain Relevance 0.24
These results suggest that both arachidonate and bradykinin-induced bronchoconstriction are mediated through the generation of TXA2, while histamine- and antigen-induced bronchoconstriction are not.
Gene_expression (generation) of TXA2 associated with bradykinin
12) Confidence 0.57 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6807699 Disease Relevance 0 Pain Relevance 0.12
The authors examined the ratios of blood free polyunsaturated fatty acids (PUFA), such as 20:3n6, 20:4n6, 20:5n3, and 22:6n3, which are substrates and inhibitors of synthesis of thromboxane A2 and prostacyclins that regulate both normal blood fluidity, and platelet adhesion and primary thrombogenesis.
Gene_expression (synthesis) of thromboxane A2 in blood associated with adhesions
13) Confidence 0.57 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2273739 Disease Relevance 0.72 Pain Relevance 0.13
Plasma levels of thromboxane A2 (TXA2), an inflammatory mediator inducing platelet aggregation, bronchoconstriction, and vasoconstriction, are increased in the perioperative period.
Gene_expression (levels) of TXA2 in platelet associated with inflammation and increased venous pressure under development
14) Confidence 0.54 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.51 Pain Relevance 0.32
Plasma levels of thromboxane A2 (TXA2), an inflammatory mediator inducing platelet aggregation, bronchoconstriction, and vasoconstriction, are increased in the perioperative period.
Gene_expression (levels) of thromboxane A2 in platelet associated with inflammation and increased venous pressure under development
15) Confidence 0.54 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.50 Pain Relevance 0.32
The biosynthesis of thromboxane A2 in clotting whole blood ex vivo as well as collagen-induced platelet aggregation were determined before and up to 48 h after administration.
Spec (determined) Gene_expression (biosynthesis) of thromboxane A2 in platelet associated with coagulation disorder
16) Confidence 0.49 Published 1996 Journal Thromb. Haemost. Section Abstract Doc Link 8903001 Disease Relevance 0.10 Pain Relevance 0.46
Amongst possible mechanisms capable of influencing the aspirin's clinical effect considered (herein, are the following aspects: polymorphism and/or mutation of the cyclooxigenese-1gene, production of thromboxane A2 in macrophages and endothelial cells via cyclooxigenese-2 polymorphism of Ilb/IIIa platelet receptors, competitive interaction with non-steroidal anti-inflammatory drugs for binding with the cyclooxigenese-1 of blood platelets, and platelet activation via other pathways which are not blocked by aspirin.
Gene_expression (production) of thromboxane A2 in platelet associated with aspirin, inflammation and cinod
17) Confidence 0.47 Published 2007 Journal Angiol Sosud Khir Section Abstract Doc Link 18004254 Disease Relevance 0.09 Pain Relevance 0.40
The evidence favouring the role of platelets is: 1) the aggregability of platelets is increased in the morning where the incidence of MI and sudden cardiac death has been shown to be high, 2) shortened bleeding time and increased mean platelet volume in the acute phase of MI, 3) the synthesis of proaggregatory thromboxane A2 is increased in the acute phase of MI and in UAP, 4) a high platelet count and an increased ADP-induced platelet aggregation predispose to MI and death in healthy males, 5) high mean platelet volume and increased spontaneous platelet aggregation are risk factors for MI and death in patients with a recent MI, 6) the platelet inhibitor, acetylsalicylic acid, has been shown to reduce the incidence of MI and mortality in patients with silent myocardial ischaemia, stable and unstable angina pectoris and in patients with MI.
Gene_expression (synthesis) of thromboxane A2 in platelets associated with aspirin, angina, coronary artery disease, hemorrhage, death and myocardial infarction
18) Confidence 0.47 Published 1995 Journal Ugeskr. Laeg. Section Abstract Doc Link 7652964 Disease Relevance 2.36 Pain Relevance 0.52
Lack of production of thromboxane A2 by the sheep heart following coronary occlusion.
Gene_expression (production) of thromboxane A2 in heart associated with anesthesia and coronary heart disease
19) Confidence 0.47 Published 1986 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Title Doc Link 2872003 Disease Relevance 0.34 Pain Relevance 0.10
U-46619 significantly augmented the CBF-oscillations induced by L-NAME while inhibition of endogenous TXA2 synthesis by ozagrel (10 mg/kg iv.) attenuated it.
Gene_expression (synthesis) of TXA2
20) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013104 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox