INT297804

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.31
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrp5) endoplasmic reticulum (Lrp5) plasma membrane (Lrp5)
Anatomy Link Frequency
Mouse 1
Lrp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 29 98.14 Very High Very High Very High
antagonist 12 50.00 Quite Low
Potency 1 40.64 Quite Low
Neuropeptide 2 21.44 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 43 98.76 Very High Very High Very High
Bone Cancer 25 97.84 Very High Very High Very High
Starvation 23 95.20 Very High Very High Very High
Syndrome 34 94.32 High High
Intellectual Impairment 1 86.80 High High
Deafness 1 85.88 High High
Blindness 1 84.84 Quite High
Obesity 32 83.96 Quite High
Body Weight 9 83.64 Quite High
Stress Fractures 53 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While not discounting the potential importance of serotonin-based therapies, this paper primarily focuses on the development of agents that potentially target LRP5, and the related proteins LRP6 and LRP4, in the bone itself.

2.

Regulation (target) of LRP5 associated with serotonin
1) Confidence 0.60 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.23
Mouse studies demonstrated that mutations in Lrp5 affect bone formation sensitivity in response to normal mechanical loading [45,46], and thus the LRP5 haplotype A-G-G-C might affect bone sensitivity and response to mechanical loading.
Regulation (affect) of Lrp5 in Mouse
2) Confidence 0.45 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.82 Pain Relevance 0
In addition, changes in both LRP5 and LRP6 have been linked to alterations in glucose homeostasis and lipid metabolism [38–43], although it is not certain whether these latter functions are dependent on the Wnt/?
Regulation (changes) of LRP5
3) Confidence 0.44 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.22 Pain Relevance 0
During the early part of this past decade, several reports linked changes in bone mass to alterations in LRP5.
Regulation (alterations) of LRP5
4) Confidence 0.27 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.49 Pain Relevance 0
This work has established LRP5 as a major target for drug development to treat osteoporosis and other bone diseases.
Regulation (target) of LRP5 associated with osteoporosis and bone cancer
5) Confidence 0.27 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.20 Pain Relevance 0.04
We found a modest decrease of Ndp transcripts in the hypothalami of deprived pups, without changes in Frizzled4 and Lrp5 transcript levels.
Neg (without) Regulation (changes) of Lrp5
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.58 Pain Relevance 0

General Comments

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