INT29781

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Context Info
Confidence 0.00
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PDYN, Npr1) cell death (PDYN) extracellular region (PDYN)
intracellular (Npr1)
Anatomy Link Frequency
locus coeruleus 1
PDYN (Homo sapiens)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
Morphine 6 99.90 Very High Very High Very High
Locus ceruleus 7 99.48 Very High Very High Very High
Raphe 1 98.32 Very High Very High Very High
agonist 1 95.72 Very High Very High Very High
opiate 8 94.64 High High
antagonist 1 94.00 High High
narcan 1 93.56 High High
tolerance 3 43.76 Quite Low
addiction 2 42.64 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 98.04 Very High Very High Very High
Bordatella Infection 2 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acutely, morphine and D-ala2-D-leu-enkephalin (DADLE) inhibited adenylate cyclase in vitro in locus coeruleus (LC), dorsal raphe, frontal cortex and neostriatum and the inhibition by each agonist was blocked by the opiate-receptor antagonist naloxone.
D-ala2-D-leu-enkephalin Negative_regulation (inhibited) of cyclase in locus coeruleus associated with locus ceruleus, narcan, enkephalin, morphine, antagonist, agonist, urological neuroanatomy, opiate and raphe
1) Confidence 0.00 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2843624 Disease Relevance 0.22 Pain Relevance 0.84

General Comments

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