INT297823

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ndp) extracellular region (Ndp)
Anatomy Link Frequency
brain 1
Ndp (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 5 22.16 Low Low
Neuropeptide 10 17.36 Low Low
member 8 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intellectual Impairment 5 99.92 Very High Very High Very High
Deafness 5 99.00 Very High Very High Very High
Blindness 5 97.96 Very High Very High Very High
Disease 10 94.88 High High
Starvation 115 94.76 High High
Stress 55 91.20 High High
Sprains And Strains 5 90.44 High High
Syndrome 105 86.08 High High
Hyperphagia 40 76.28 Quite High
Failure To Thrive 20 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Five of the chosen six with high to modest level of expression (Ing2, Pgpep1, Brms1l, Ndp, Snx1 and Mett10d) were validated by real-time RT-PCR analysis (all but Ing2) (Fig. 2B and Table 1).


Gene_expression (expression) of Ndp
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.09 Pain Relevance 0
Ndp is expressed in many brain regions in the adult, but its expression in hypothalamus has not previously been reported [32].
Gene_expression (expressed) of Ndp in brain
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.58 Pain Relevance 0
Norrin, the protein product of Ndp, is a high-affinity ligand for Wnt co-receptors FRIZZLED 4 and LRP 5 [31].
Gene_expression (product) of Norrin
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.59 Pain Relevance 0
But we detected transcription changes in unexpected genes, Nanos2 and Pdk4, which are increased by roughly 2-fold and 1.5-fold respectively, and Ndp, Pgpep1, Brms1l, Mett10d and Snx1, which are reduced by 25–55% (Figure 2 and Table 1).


Gene_expression (detected) of Ndp
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.24 Pain Relevance 0
Unlike in adult rodents, expression levels of Nanos2 and Pdk4 were increased, and those of Pgpep1, Ndp, Brms1l, Mett10d, and Snx1 were decreased after neonatal deprivation.
Gene_expression (expression) of Ndp
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827556 Disease Relevance 1.00 Pain Relevance 0

General Comments

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