INT297831

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl1) plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
HeLa 1
afferent neurons 1
F2rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 35 97.40 Very High Very High Very High
Inflammation 40 94.40 High High
Hyperalgesia 1 92.80 High High
Central nervous system 4 92.44 High High
cytokine 13 92.28 High High
agonist 3 66.16 Quite High
qutenza 4 55.76 Quite High
c fibre 3 55.24 Quite High
Nerve growth factor 19 23.12 Low Low
Neuropeptide 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 94.40 High High
Starvation 23 93.76 High High
Hyperalgesia 1 92.80 High High
Stress 24 69.72 Quite High
Apoptosis 3 34.64 Quite Low
Cancer 3 33.44 Quite Low
Adhesions 1 32.72 Quite Low
Hypoxia 1 31.48 Quite Low
Disease 7 29.40 Quite Low
Hypersensitivity 4 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tryptase has recently been shown to cleave PAR2 on primary spinal afferent neurons, which causes the release of substance P, activation of the neurokinin 1 receptor, and amplification of inflammation and thermal and mechanical hyperalgesia [37].
Protein_catabolism (cleave) of PAR2 in afferent neurons associated with hyperalgesia, inflammation and substance p
1) Confidence 0.10 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.19 Pain Relevance 0.56
In HeLa cells, SNX1 is essential for the degradation of the G-protein coupled receptor PRP1 (protease-activated receptor-1) [41].
Protein_catabolism (degradation) of protease-activated receptor-1 in HeLa
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.31 Pain Relevance 0.05

General Comments

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