INT297864

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Anatomy Link Frequency
thymus 6
liver 1
bone marrow 1
adipose tissue 1
spleen 1
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 195 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.96 Very High Very High Very High
Hyperglycemia 90 99.32 Very High Very High Very High
Obesity 5 96.48 Very High Very High Very High
Injury 10 77.36 Quite High
Targeted Disruption 45 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of Transcription (transcription) of insulin gene in thymus associated with hyperglycemia, diabetes mellitus and obesity
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.46 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in liver Transcription (transcription) of insulin gene in thymus associated with hyperglycemia, diabetes mellitus and obesity
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.46 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in spleen Transcription (transcription) of insulin gene in thymus associated with hyperglycemia, diabetes mellitus and obesity
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.46 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in adipose tissue Transcription (transcription) of insulin gene in thymus associated with hyperglycemia, diabetes mellitus and obesity
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.46 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in bone marrow Transcription (transcription) of insulin gene in thymus associated with hyperglycemia, diabetes mellitus and obesity
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.46 Pain Relevance 0

General Comments

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