INT297865

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Anatomy Link Frequency
liver 2
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 39 96.96 Very High Very High Very High
agonist 30 81.84 Quite High
Inflammatory response 2 48.20 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 18 99.54 Very High Very High Very High
Hepatocellular Cancer 2 96.72 Very High Very High Very High
Targeted Disruption 9 96.50 Very High Very High Very High
Obesity 15 56.32 Quite High
Diabetes Mellitus 19 54.40 Quite High
INFLAMMATION 16 47.84 Quite Low
Disease 1 47.52 Quite Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Nash(non-alcoholic Steatohepatitis) 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novelty of our investigation lies in the application of BLI to the model in which the transgenic mice expressing the reporter gene coding for the firefly-luciferase driven by a rat insulin gene promoter were treated with STZ to induce hyperglycemia, a condition known to induce the insulin gene expression in liver cells.
Positive_regulation (induce) of Gene_expression (expression) of insulin gene in liver associated with hyperglycemia, targeted disruption and imagery
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.25 Pain Relevance 0.20
activation reduced expression of lipogenic genes, including Fasn, Gpam, and SREBP1c, while Insig1 expression was increased by PPAR?
Positive_regulation (including) of Gene_expression (expression) of Insig1
2) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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