INT297867

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.86
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2)
carbohydrate metabolic process (Ins2) cytoplasm (Ins2)
Anatomy Link Frequency
thymus 6
liver 3
bone marrow 1
spleen 1
adipose tissue 1
Ins2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 234 89.32 High High
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 108 99.96 Very High Very High Very High
Hyperglycemia 108 99.32 Very High Very High Very High
Obesity 6 97.52 Very High Very High Very High
Injury 12 79.44 Quite High
Targeted Disruption 54 69.04 Quite High
Body Weight 12 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0
As shown in Figure 5, the expression of both the endogenous insulin-I and insulin-II genes were elevated in the liver RNA samples from animals exposed to hyperglycemia for 8 days (samples 3, 4, and 5).
Positive_regulation (elevated) of Gene_expression (expression) of insulin-II in liver associated with hyperglycemia
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.52 Pain Relevance 0.04
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in liver Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in adipose tissue Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in bone marrow Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0
Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].
Positive_regulation (activates) of in spleen Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

General Comments

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