INT297867

Context Info Confidence 0.48 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 2.86 Pain Relevance 0.04

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2) carbohydrate metabolic process (Ins2) cytoplasm (Ins2)

Anatomy Link Frequency thymus 6 liver 3 bone marrow 1 spleen 1 adipose tissue 1 Ins2 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 234 89.32 anesthesia 6 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 108 99.96 Hyperglycemia 108 99.32 Obesity 6 97.52 Injury 12 79.44 Targeted Disruption 54 69.04 Body Weight 12 5.00 Adhesions 6 5.00 Disease 6 5.00

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Protein

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Event

Anatomy

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Speculation

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Disease term

Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].

Positive_regulation (activates) of Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity

1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

As shown in Figure 5, the expression of both the endogenous insulin-I and insulin-II genes were elevated in the liver RNA samples from animals exposed to hyperglycemia for 8 days (samples 3, 4, and 5).

Positive_regulation (elevated) of Gene_expression (expression) of insulin-II in liver associated with hyperglycemia

2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.52 Pain Relevance 0.04

Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].

Positive_regulation (activates) of in liver Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity

3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].

Positive_regulation (activates) of in adipose tissue Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity

4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].

Positive_regulation (activates) of in bone marrow Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity

5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

Interestingly, it has been recently observed that hyperglycemia, with or without overt diabetes, activates insulin gene transcription and proinsulin production in multiple extrapancreatic tissues including liver, spleen, adipose tissue, thymus and bone marrow [5].

Positive_regulation (activates) of in spleen Gene_expression (production) of proinsulin in thymus associated with hyperglycemia, diabetes mellitus and obesity

6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.47 Pain Relevance 0

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