INT297904

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.19
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo3) nucleus (Foxo3) embryo development (Foxo3)
DNA binding (Foxo3) transcription factor binding (Foxo3) response to stress (Foxo3)
Foxo3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 57 92.92 High High
Inflammatory response 6 90.24 High High
chemokine 4 69.68 Quite High
cytokine 8 69.12 Quite High
ischemia 14 29.36 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 3 100.00 Very High Very High Very High
Diabetes Mellitus 221 99.84 Very High Very High Very High
Myocardial Infarction 316 99.20 Very High Very High Very High
Stress 33 98.32 Very High Very High Very High
Death 10 96.36 Very High Very High Very High
Fibrosis 49 92.92 High High
Apoptosis 166 91.88 High High
Hypertrophy 57 91.44 High High
INFLAMMATION 29 90.24 High High
Sprains And Strains 12 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Key changes in the posttranslational modification and expression of stress response proteins were decreased Akt phosphorylation and a concomitant increase in FOXO3a activation.
Positive_regulation (activation) of FOXO3a associated with stress
1) Confidence 0.57 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.85 Pain Relevance 0.09
Akt - FOXO3a-dephosphorylation and FOXO3a-activation in diabetic Goto-Kakizaki rats after MI
Positive_regulation (activation) of FOXO3a associated with diabetes mellitus and myocardial infarction
2) Confidence 0.41 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.13 Pain Relevance 0.03
Akt - FOXO3a-dephosphorylation and FOXO3a-activation in diabetic Goto-Kakizaki rats after MI
Positive_regulation (activation) of FOXO3a associated with diabetes mellitus and myocardial infarction
3) Confidence 0.41 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.06 Pain Relevance 0.03
The decrease in phosphorylation was associated with increased nuclear FOXO3a-translocation and DNA binding as assessed by electrophoretic mobility shift assay.
Positive_regulation (increased) of FOXO3a
4) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.83 Pain Relevance 0
The most prominent mechanism appears its ability to induce several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF [4].
Positive_regulation (induce) of Foxo3a associated with aging
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 1.32 Pain Relevance 0.05
A comparison between groups CLP+O3 and CLP+O2 showed no significant difference (p=0.54).
Positive_regulation (groups) of O3
6) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827707 Disease Relevance 0 Pain Relevance 0.10

General Comments

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