INT29794

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 13
Total Number 19
Disease Relevance 5.02
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
neurons 2
muscle 1
skeletal muscles 1
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 236 100.00 Very High Very High Very High
Pain 23 100.00 Very High Very High Very High
Codeine 4 100.00 Very High Very High Very High
dopamine receptor 86 99.96 Very High Very High Very High
narcan 7 99.92 Very High Very High Very High
Dopamine 987 99.90 Very High Very High Very High
Opioid 15 99.08 Very High Very High Very High
tolerance 18 98.76 Very High Very High Very High
MU agonist 5 98.20 Very High Very High Very High
agonist 262 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 102 100.00 Very High Very High Very High
Ganglion Cysts 24 99.02 Very High Very High Very High
Pain 17 98.96 Very High Very High Very High
Targeted Disruption 14 98.30 Very High Very High Very High
Hypokinesia 72 98.16 Very High Very High Very High
Cognitive Disorder 21 98.00 Very High Very High Very High
Movement Disorders 42 97.08 Very High Very High Very High
Hypertension 2 90.96 High High
Obesity 126 90.04 High High
Insulin Resistance 1 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-2 antagonists were ineffective in modifying the motivational properties of opioid agonists and naloxone.
Regulation (ineffective) of D-2 associated with mu agonist, antagonist and narcan
1) Confidence 0.44 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2844553 Disease Relevance 0 Pain Relevance 1.20
Our hypothesis suggests a different role of D1 and D2 receptors in movement regulation.
Regulation (role) of D2
2) Confidence 0.24 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.05 Pain Relevance 0.25
Our hypothesis of an integrative system that influences D1-mediated tone inhibition and D2-accelerated contraction depending on synaptic dopamine concentrations helps to conceptualize pathophysiological mechanisms underlying the clinical symptoms in several dopamine-related movement disorders.
Regulation (influences) of D2 associated with movement disorders and dopamine
3) Confidence 0.21 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.43 Pain Relevance 0.72
Thus both D1-mediated muscle tone inhibition and D2-accelerated contraction may be synchronically regulated during movement in the antagonist muscle pair.
Spec (may) Regulation (regulated) of D2 in muscle associated with antagonist
4) Confidence 0.21 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.13 Pain Relevance 0.38
As a first step, however, the currently available knock-out models can be used to investigate our hypotheses and to establish the locomotor effects of selective D1 and D2 ligands.
Regulation (effects) of D2 associated with targeted disruption
5) Confidence 0.21 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.24 Pain Relevance 0.15
There was, however, a small, but significant, effect of nonMHC-d2 on health, with individuals with greater nonMHC-d2 reporting fewer symptoms (better health) over the four-month period (Table 3).
Regulation (effect) of d2
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.17 Pain Relevance 0
Central to this problem is whether any of the DIO2 polymorphisms reported to date affect the activity and/or kinetic properties of D2.
Spec (whether) Regulation (affect) of D2
7) Confidence 0.16 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.34 Pain Relevance 0
This molecular finding serves as the basis for inducing DA release naturally, also causing the same induction of D2-directed mRNA and thus proliferation of D2 receptors in the human.
Regulation (proliferation) of D2 associated with dopamine
8) Confidence 0.15 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.45 Pain Relevance 0.48
The down-regulation of dopamine receptors was selective for D2 dopamine receptors.
Regulation (selective) of D2 associated with dopamine receptor
9) Confidence 0.15 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.36 Pain Relevance 0.46
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Regulation (regulation) of D2 associated with dopamine receptor, mu opioid receptor and enkephalin
10) Confidence 0.15 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.12 Pain Relevance 0.50
Interestingly, continuous infusion of quinpirole caused a significant down-regulation of striatal D2 dopamine receptors without significantly changing the density of D1 receptors.
Regulation (regulation) of D2 associated with dopamine receptor
11) Confidence 0.13 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.75 Pain Relevance 0.38
Effect of large-field tactile LFS on discrimination thresholds of the right d2
Regulation (Effect) of d2 associated with li-fraumeni syndrome
12) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2244613 Disease Relevance 0.36 Pain Relevance 0
Effect of small-field tactile HFS on discrimination thresholds of the right d2
Regulation (Effect) of d2
13) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2244613 Disease Relevance 0.18 Pain Relevance 0
The effects of D-Met2, Pro5-enkephalinamide (EA) on pain tolerance and some cognitive functions have been examined in healthy male volunteers.
Regulation (effects) of D-Met2 associated with pain, cognitive disorder and tolerance
14) Confidence 0.07 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3092271 Disease Relevance 0.48 Pain Relevance 0.34
Thus the single nigral axon may influence both D1 and D2 receptors in the pool of striatal neurons responsible for movement activity of agonist–antagonist muscle pair.
Spec (may) Regulation (influence) of D2 in neurons associated with antagonist and agonist
15) Confidence 0.06 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.49
Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation

The article presents the hypothesis that nigrostriatal dopamine may regulate movement by modulation of tone and contraction in skeletal muscles through a concentration-dependent influence on the postsynaptic D1 and D2 receptors on the follow manner: nigrostriatal axons innervate both receptor types within the striatal locus somatotopically responsible for motor control in agonist/antagonist muscle pair around a given joint.

Spec (may) Regulation (regulate) of D2 in skeletal muscles associated with dopamine, antagonist, dopamine receptor and agonist
16) Confidence 0.06 Published 2010 Journal J Neural Transm Section Title Doc Link PMC3000910 Disease Relevance 0 Pain Relevance 0.47
-values of d1, d2, d3, d4, and d5 in post (p ?
Regulation (values) of d2
17) Confidence 0.06 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682400 Disease Relevance 0 Pain Relevance 0
Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man.
Regulation (Effects) of D-Met2 associated with pain, cognitive disorder, tolerance and codeine
18) Confidence 0.05 Published 1986 Journal Psychopharmacology (Berl.) Section Title Doc Link 3092271 Disease Relevance 0.61 Pain Relevance 0.84
Electrophysiologic studies on vagal afferent ganglion neuron cell bodies have demonstrated excitatory affects of several prostaglandins, including prostaglandin E2, D2, and I2 (prostacyclin) [50,54].
Regulation (affects) of D2 in neuron associated with ganglion cysts
19) Confidence 0.01 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.33 Pain Relevance 0.17

General Comments

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