INT297976

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK8) nucleus (CDK8)
CDK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 77.76 Quite High
Somatostatin 16 70.80 Quite High
Inflammation 8 67.00 Quite High
cytokine 8 37.20 Quite Low
withdrawal 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 16 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Stress 32 95.88 Very High Very High Very High
Colon Cancer 4 85.36 High High
Shock 16 77.88 Quite High
Apoptosis 32 73.04 Quite High
Aging 228 72.92 Quite High
INFLAMMATION 8 67.00 Quite High
Adhesions 4 34.84 Quite Low
Fever 4 15.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclin-dependent kinase 8 (CDK8) acts as a stimulus-specific positive coregulator within the p53 system [54].
Positive_regulation (dependent) of CDK8
1) Confidence 0.42 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.50 Pain Relevance 0
Several significantly downregulated genes were also found to be present in the senescent cells; these included alpha-2-glycoprotein 1, tumor necrosis factor superfamily, member 13b, integrin-linked kinase-2, the G1 to S phase transition 2 gene, cell division cycle 2-like 6 (CDK8-like) gene, and Ras homolog gene family member H.


Positive_regulation (included) of CDK8 associated with necrosis and cancer
2) Confidence 0.37 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.52 Pain Relevance 0.06
Cyclin-dependent kinase 8 (CDK8) acts as a stimulus-specific positive coregulator within the p53 system [54].
Positive_regulation (dependent) of kinase 8
3) Confidence 0.37 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.50 Pain Relevance 0
Three important genes related to cell signaling showed significant downregulation in senescent cells: Mitogen-activated protein kinase 8 interacting protein 2, mitogen-activated protein kinase kinase kinase 11, and mitogen-activated protein kinase 2.
Positive_regulation (activated) of kinase 8
4) Confidence 0.37 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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