INT297991

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GAS1) cell cycle (GAS1)
Anatomy Link Frequency
fibroblasts 1
GAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 68.60 Quite High
Somatostatin 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 57 97.60 Very High Very High Very High
Intervertebral Disk Degeneration 8 85.44 High High
Necrosis 4 63.12 Quite High
Apoptosis 8 62.16 Quite High
Intervertebral Disk Displacement 2 60.04 Quite High
Stress 8 5.00 Very Low Very Low Very Low
Retinoblastoma 6 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using laser capture microdissection and microarray analysis, this study (described in more detail below) identified two senescence-related genes which were significantly up-regulated in more degenerated discs compared to healthier discs [20]: growth arrest-specific 1 gene (GAS) (which inhibits DNA synthesis, inhibits cell cycle progression in vitro, and is expressed in senescent fibroblasts [21-23].
Gene_expression (expressed) of arrest-specific 1 gene in fibroblasts associated with aging
1) Confidence 0.19 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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