INT297997

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK8) nucleus (CDK8)
Anatomy Link Frequency
finger 1
annulus 1
CDK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 16 99.40 Very High Very High Very High
cytokine 8 83.20 Quite High
metalloproteinase 8 79.48 Quite High
Inflammation 8 68.72 Quite High
withdrawal 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 228 99.62 Very High Very High Very High
Colon Cancer 4 97.88 Very High Very High Very High
Shock 16 95.44 Very High Very High Very High
Stress 32 91.68 High High
Apoptosis 32 73.04 Quite High
INFLAMMATION 8 68.72 Quite High
Adhesions 4 61.16 Quite High
Cancer 8 48.16 Quite Low
Necrosis 16 47.68 Quite Low
Fever 4 36.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our analyses, we found a significant downregulation of CDK8 in senescent annulus cells compared to non-senescent cells.
Negative_regulation (downregulation) of CDK8 in annulus
1) Confidence 0.49 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.52 Pain Relevance 0
Three important genes related to cell signaling showed significant downregulation in senescent cells: Mitogen-activated protein kinase 8 interacting protein 2, mitogen-activated protein kinase kinase kinase 11, and mitogen-activated protein kinase 2.
Negative_regulation (downregulation) of kinase 8
2) Confidence 0.32 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.28 Pain Relevance 0.07
Another known gene related to senescence, cyclin-dependent kinase 8, showed significant downregulation in senescent cells.
Negative_regulation (downregulation) of kinase 8 associated with aging
3) Confidence 0.32 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.62 Pain Relevance 0.11
Genes with established relationships to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, p28ING5, sphingosine-1-phosphate receptor 2 and somatostatin receptor 3; cyclin-dependent kinase 8 showed significant downregulation in senescent cells.
Negative_regulation (downregulation) of kinase 8 in finger associated with aging and somatostatin
4) Confidence 0.32 Published 2010 Journal BMC Biotechnol Section Abstract Doc Link PMC2828399 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

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