INT298

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 6.82
Pain Relevance 7.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
lymphocyte 2
plasma 1
blood 1
heart 1
ovary 1
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 14 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
corticosteroid 1 100.00 Very High Very High Very High
analgesia 16 99.90 Very High Very High Very High
Mexiletine 8 99.86 Very High Very High Very High
anesthesia 33 99.72 Very High Very High Very High
Eae 1 99.68 Very High Very High Very High
opioid receptor 1 99.36 Very High Very High Very High
antidepressant 4 98.86 Very High Very High Very High
Catecholamine 3 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 25 99.76 Very High Very High Very High
Myocardial Infarction 5 99.04 Very High Very High Very High
Pyloric Stenosis 2 98.68 Very High Very High Very High
Coronary Artery Disease 14 98.54 Very High Very High Very High
Heart Rate Under Development 33 98.32 Very High Very High Very High
Hypertension 9 98.02 Very High Very High Very High
INFLAMMATION 5 97.92 Very High Very High Very High
Stress 2 97.80 Very High Very High Very High
Cv Unclassified Under Development 2 97.24 Very High Very High Very High
Hypersensitivity 2 96.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic stimulation of beta-ARs, via heightened activity of the sympathoadrenal system, leads to diminished beta-AR function.
Negative_regulation (diminished) of beta-AR
1) Confidence 0.59 Published 2010 Journal J. Endocrinol. Section Abstract Doc Link 20603265 Disease Relevance 0.06 Pain Relevance 0.03
[A case of amphetamine-induced down-regulation of beta-adrenoceptor].
Negative_regulation (down-regulation) of beta-adrenoceptor
2) Confidence 0.51 Published 2001 Journal Masui Section Title Doc Link 11758335 Disease Relevance 0.10 Pain Relevance 0.40
We speculate that the down-regulation of beta-adrenoceptor induced by the sympathomimetic action of amphetamine, might be a major cause of refractory hypotension.
Negative_regulation (down-regulation) of beta-adrenoceptor associated with pressure volume 2 under development
3) Confidence 0.51 Published 2001 Journal Masui Section Abstract Doc Link 11758335 Disease Relevance 0.17 Pain Relevance 0.37
To examine the possibility of beta-adrenoceptor desensitization due to intraoperative adrenergic activation (surgical stress), the alterations of human lymphocyte beta-adrenergic receptor density and affinity observed after anesthesia and surgery were studied using (-)125I-iodocyanopindolol binding in 19 patients undergoing noncardiac surgical procedures with general anesthesia (thiopental, fentanyl, and halothane or isoflurane).
Negative_regulation (desensitization) of beta-adrenoceptor in lymphocyte associated with stress, anesthesia, isoflurane and halothane
4) Confidence 0.43 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2163590 Disease Relevance 0.10 Pain Relevance 0.36
Isoproterenol dose-response curves are a safe means to assess the degree of beta-adrenoceptor blockade during anesthesia and the postoperative period.
Negative_regulation (blockade) of beta-adrenoceptor associated with anesthesia
5) Confidence 0.43 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 2858167 Disease Relevance 0.34 Pain Relevance 0.44
Patients with hypertension or ischemic heart disease are often treated with beta-adrenoceptor antagonists, yet the degree of beta-adrenoceptor blockade has rarely been studied in relation to anesthesia.
Negative_regulation (blockade) of beta-adrenoceptor in heart associated with anesthesia, coronary artery disease, antagonist and hypertension
6) Confidence 0.43 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 2858167 Disease Relevance 0.35 Pain Relevance 0.38
Assessment of beta-adrenoceptor blockade during anesthesia in humans: use of isoproterenol dose-response curves.
Negative_regulation (blockade) of beta-adrenoceptor associated with anesthesia
7) Confidence 0.43 Published 1985 Journal Anesth. Analg. Section Title Doc Link 2858167 Disease Relevance 0.41 Pain Relevance 0.52
The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant beta-adrenoceptor blockade in the early stages of acute myocardial infarction in man.
Negative_regulation (blockade) of beta-adrenoceptor in plasma associated with myocardial infarction
8) Confidence 0.43 Published 1976 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 975619 Disease Relevance 0.63 Pain Relevance 0.22
The adrenergic beta-receptor blockade induced a slight increase in pulse rate with almost no change in arterial blood pressure.
Negative_regulation (blockade) of adrenergic beta-receptor in blood
9) Confidence 0.43 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 26160 Disease Relevance 0.62 Pain Relevance 0.34
Four patients operated on without adrenergic beta-receptor blockade formed the control group.
Neg (without) Negative_regulation (blockade) of adrenergic beta-receptor
10) Confidence 0.43 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 26160 Disease Relevance 0.50 Pain Relevance 0.27
It does, however, seem to be compatible with an adrenergic beta-receptor blockade, which in turn provides partial protection against adrenaline-induced arrhythmias.
Negative_regulation (blockade) of adrenergic beta-receptor
11) Confidence 0.43 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 26160 Disease Relevance 0.56 Pain Relevance 0.34
Cardiovascular effects of local adrenaline infiltration during neurolept analgesia and adrenergic beta-receptor blockade in man.
Negative_regulation (blockade) of adrenergic beta-receptor associated with analgesia
12) Confidence 0.43 Published 1978 Journal Acta Anaesthesiol Scand Section Title Doc Link 26160 Disease Relevance 0.55 Pain Relevance 0.35
The response to surgery of the beta AR system on these patients differed from that of patients undergoing cardiothoracic and abdominal surgery in whom we previously found postoperative down-regulation and desensitization of the beta AR system.
Negative_regulation (down-regulation) of beta AR
13) Confidence 0.41 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610861 Disease Relevance 0.09 Pain Relevance 0.29
Cardiac surgery causes desensitization of the beta-adrenergic receptor system of human lymphocytes.
Negative_regulation (desensitization) of beta-adrenergic receptor in lymphocytes
14) Confidence 0.41 Published 1992 Journal Anesth. Analg. Section Title Doc Link 1309962 Disease Relevance 0 Pain Relevance 0.54
The responses were also examined in the presence of opioid receptor blocker, nitric oxide synthase inhibitor, beta-adrenoceptor blocker, or cyclooxygenase inhibitor.
Negative_regulation (inhibitor) of beta-adrenoceptor associated with opioid receptor
15) Confidence 0.35 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11273940 Disease Relevance 0 Pain Relevance 0.48
Amrinone, a phosphodiesterase inhibitor, and epinephrine, an alpha- and beta-adrenergic receptor agonist, are inotropic drugs used during cardiac surgery to reverse myocardial depression after cardiopulmonary bypass.
Negative_regulation (inhibitor) of beta-adrenergic receptor associated with depression, cv unclassified under development and agonist
16) Confidence 0.35 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8214647 Disease Relevance 0.10 Pain Relevance 0.10
Sudden cessation of propranolol for short periods may be preferable to tapering the dosage if prolonged periods of sub-optimal beta-adrenoceptor blockade are to be avoided.
Negative_regulation (blockade) of beta-adrenoceptor
17) Confidence 0.33 Published 1977 Journal Chest Section Abstract Doc Link 830495 Disease Relevance 0.51 Pain Relevance 0.46
The responses to phentolamine could be blocked by beta adrenergic receptor blockade.
Negative_regulation (blockade.) of beta adrenergic receptor
18) Confidence 0.26 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2880278 Disease Relevance 0.40 Pain Relevance 0
The allergic rabbit model has been used extensively in assessing the various classes of anti-asthma drugs and is sensitive to similar drugs as patients with asthma, including beta-adrenoceptor agonists, corticosteroids, phosphodiesterase inhibitors and theophylline.
Negative_regulation (inhibitors) of beta-adrenoceptor associated with asthma, corticosteroid, hypersensitivity and agonist
19) Confidence 0.18 Published 2008 Journal Pulm Pharmacol Ther Section Abstract Doc Link 18430597 Disease Relevance 0.89 Pain Relevance 0.35
A biphasic concentration response curve was observed for the inhibitory activity of all beta-adrenoceptor agonists on IFN-gamma production by PBMC 24 h after PHA activation.
Negative_regulation (activity) of beta-adrenoceptor in PBMC associated with agonist
20) Confidence 0.18 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.06 Pain Relevance 0.16

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