INT298000

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.03

cell differentiation (Gadd45b) nucleus (Gadd45b) response to stress (MAP3K4) cytoplasm (MAP3K4)

MAP3K4 (Homo sapiens) Gadd45b (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 1 69.44 Somatostatin 4 5.00 metalloproteinase 2 5.00 cytokine 2 5.00 Inflammation 2 5.00 alcohol 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Retinoblastoma 6 88.96 Aging 57 67.76 Apoptosis 8 59.76 Necrosis 4 59.24 Cancer 2 9.20 Intervertebral Disk Degeneration 8 5.00 Stress 8 5.00 Shock 4 5.00 Intervertebral Disk Displacement 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpression of GADD45beta has been shown to activate p38 via MTK1 [36-38].

MTK1 Positive_regulation (activate) of Gene_expression (Overexpression) of GADD45beta

1) Confidence 0.27 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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