INT29802

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Context Info
Confidence 0.64
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.04
Pain Relevance 9.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
spinal cords 2
plasma 1
Mouse 1
brain 1
thymocytes 1
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 123 100.00 Very High Very High Very High
opioid receptor 37 100.00 Very High Very High Very High
Kappa opioid receptor 13 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
Spinal sensitization 2 99.76 Very High Very High Very High
antinociception 15 99.52 Very High Very High Very High
mu opioid receptor 4 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 57 99.48 Very High Very High Very High
INFLAMMATION 32 99.16 Very High Very High Very High
Targeted Disruption 109 98.80 Very High Very High Very High
Hypoxia 12 98.70 Very High Very High Very High
Cancer 13 97.88 Very High Very High Very High
Anxiety Disorder 1 96.64 Very High Very High Very High
Toxicity 3 95.76 Very High Very High Very High
Death 10 95.68 Very High Very High Very High
Hyperalgesia 10 92.68 High High
Inflammatory Pain 18 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the view that a sensitization of opioid receptors occurs during acute inflammation of the gut.
Localization (sensitization) of receptors in gut associated with inflammation and opioid receptor
1) Confidence 0.64 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8035336 Disease Relevance 0.57 Pain Relevance 0.82
What aspects of learning EphA receptors mediate have not been studied?
Localization (learning) of receptors
2) Confidence 0.38 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10701657 Disease Relevance 0.39 Pain Relevance 0.25
Mouse CAPER (HCC1.3) was reported to enhance activation of ER?
Localization (reported) of CAPER in Mouse
3) Confidence 0.25 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
These experiments reveal the localization of mu and delta opioid receptors reached after i.c.v. injection and provide evidence to support the suggestion that delta-opioid receptors contribute little or none to the supraspinal antinociception.
Localization (localization) of receptors associated with antinociception and delta opioid receptors
4) Confidence 0.24 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247256 Disease Relevance 0 Pain Relevance 0.73
In the current study a fluorescein isothiocyanate-conjugated naltrexone (FITC-NTX) derivative in the absence or presence of naltrexone, as a competitor, was used to detect opioid receptors on thymocytes and then on splenocytes of normal and tumor bearing Balb/c mice.
Localization (detect) of receptors in thymocytes associated with cancer and opioid receptor
5) Confidence 0.21 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15829417 Disease Relevance 0.44 Pain Relevance 0.32
Since nitrous oxide is thought to cause the neuronal release of endogenous opioid peptide to stimulate opioid receptors, this study was designed to identify the opioid peptides involved, especially in the spinal cord, by determining whether nitrous oxide antinociception can be differentially inhibited by intrathecally (i. t.) administered antisera to different opioid peptides.
Localization (release) of receptors in spinal cord associated with antinociception, endogenous opioid, opioid receptor, opioid and spinal cord
6) Confidence 0.12 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10895052 Disease Relevance 0 Pain Relevance 0.88
This may be due to the presence of pronociceptive A(2A) receptors on sensory nerves, and if so spinal cords from A(2A) receptor knockout mice may have altered neurochemical responses to a nociceptive stimulus.
Localization (presence) of receptors in spinal cords associated with nociception and targeted disruption
7) Confidence 0.12 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20570711 Disease Relevance 0.59 Pain Relevance 0.39
In rodent brain membranes, the 5-benzyl derivative showed high affinity at the micro opioid receptor and decreased interaction with delta and kappa receptors, hence displaying a similar binding profile as 14-MM.
Localization (decreased) of receptors in brain associated with opioid receptor
8) Confidence 0.08 Published 2010 Journal Eur J Pharm Sci Section Abstract Doc Link 20600882 Disease Relevance 0.25 Pain Relevance 1.10
These results suggest that endomorphin-2 initially stimulates mu-opioid receptors, which subsequently induce the release of dynorphins that act on kappa-opioid receptors to produce antinociception.
Localization (release) of receptors associated with antinociception, kappa opioid receptor and mu opioid receptor
9) Confidence 0.07 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16394196 Disease Relevance 0 Pain Relevance 1.07
One possible cause for the decrease in delta opioid receptor expression following seven days of hypoxic exposure may be receptor down-regulation caused by an increased release of endogenous substances acting at delta receptors.
Localization (release) of receptors associated with hypoxia and opioid receptor
10) Confidence 0.04 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.77 Pain Relevance 0.56
The nonadditivity of the inhibitory effects of DTLET and DAGO on basal or forskolin-induced activation of adenylate cyclase suggested that mu and delta receptors were colocalized on a similar subpopulation of striatal cells in primary culture.
Localization (colocalized) of receptors
11) Confidence 0.03 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2845021 Disease Relevance 0.15 Pain Relevance 0.52
The antinociception induced by endomophin-2 contains additional components, which are mediated by the release of dynorphin A-(1-17) and [Met(5)]enkephalin which subsequently act on kappa-opioid receptors and delta(2)-opioid receptors to produce antinociception.
Localization (release) of receptors associated with antinociception, dynorphin, kappa opioid receptor, opioid receptor and enkephalin
12) Confidence 0.03 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11567650 Disease Relevance 0 Pain Relevance 1.14
Rather, loss of Neto1 and LEV-10 each leads to a reduction in synaptic localization of the cognate receptors, whereas loss of SOL-1 leads to a loss of function of normally distributed GLR-1.
Localization (localization) of receptors
13) Confidence 0.01 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.11
It was proposed that pathological states in the CNS may result from either acute or chronic excessive release of Glu and over-activation of its post-synaptic receptors [9-13].
Localization (release) of receptors associated with glutamate and central nervous system
14) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.36 Pain Relevance 0.69
Comparing the effect of over-expressed GRK2 and GRK3 on sequestration of kappa-receptors, we conclude that GRK3 more strongly induces kappa-receptor internalization than GRK2.
Localization (sequestration) of receptors
15) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.15
The translocation of AMPA receptors from the cytosol to the plasma membrane also requires the involvement of Stargazin.
Localization (translocation) of receptors in plasma
16) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.17
It suggests a significant membrane translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation [27].
Localization (translocation) of receptors in synapse associated with nociception
17) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.51 Pain Relevance 0.63
The localization of fluorescent receptors and GRKs was monitored by confocal microscopy before and after opioid exposure of transfected cells.
Localization (localization) of receptors associated with opioid
18) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.32

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