INT298059

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.97
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip) plasma membrane (HLA-A)
Anatomy Link Frequency
leukocyte 1
HLA-A (Homo sapiens)
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 120 68.96 Quite High
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumococcal Infection 40 97.00 Very High Very High Very High
Targeted Disruption 8 94.88 High High
Sprains And Strains 144 92.20 High High
Pneumonia 156 91.88 High High
Disease 8 82.72 Quite High
Infection 20 67.28 Quite High
Bacterial Meningitis 24 18.24 Low Low
Death 8 16.84 Low Low
Sepsis 4 6.24 Low Low
Hyperplasia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, some HLA molecules may not be able to bind to any of the peptides derived from a given protein [9], [10].
HLA Binding (bind) of peptides
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.07 Pain Relevance 0.03
Identification of PspA peptides that optimally bind human leukocyte antigen (HLA) would greatly contribute to global vaccine efforts, but this is hindered by the multitude of HLA polymorphisms.
HLA Binding (bind) of peptides in leukocyte
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2828482 Disease Relevance 0.66 Pain Relevance 0.03
The discovery of “promiscuous” or “universal” peptides that can bind multiple HLA (?
HLA Binding (bind) of peptides
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.18 Pain Relevance 0.06
Thus, the identification of peptides that bind to multiple HLA types, the so-called “promiscuous” or “universal” epitope(s), could lead to effective coverage of the human population using peptide-based vaccine.
HLA Binding (bind) of peptides
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.05 Pain Relevance 0

General Comments

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