INT2981

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Context Info
Confidence 0.42
First Reported 1977
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.41
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
blood 4
hypothalamus 2
embryo 2
Mouse 2
sperm 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 1 98.86 Very High Very High Very High
Neuropeptide 3 98.42 Very High Very High Very High
antagonist 2 95.96 Very High Very High Very High
Dismenorea 2 95.88 Very High Very High Very High
tolerance 3 91.80 High High
Pain 17 91.28 High High
Angina 1 82.52 Quite High
pain pelvic 2 82.48 Quite High
anesthesia 1 77.64 Quite High
abdominal pain 4 71.84 Quite High
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 98 100.00 Very High Very High Very High
Cancer 2 99.32 Very High Very High Very High
Reprotox - General 1 27 97.04 Very High Very High Very High
Dysmenorrhea 2 95.88 Very High Very High Very High
Pain 14 91.28 High High
Emergencies 5 87.20 High High
Carcinoma 2 83.08 Quite High
Cv General 3 Under Development 1 82.52 Quite High
Reprotox - General 3 7 82.48 Quite High
Incomplete Abortion 1 80.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the explanation for this may be that hCG production in many patients with ectopic pregnancies is normal until symptoms develop and falls thereafter as the functional trophoblastic mass is reduced by the shearing off the trophoblast from the tubal wall, which takes place with the development of the pregnancy and of symptoms.
Negative_regulation (reduced) of Gene_expression (production) of hCG associated with ectopic pregnancy
1) Confidence 0.42 Published 1982 Journal Fertil. Steril. Section Abstract Doc Link 7067849 Disease Relevance 0.39 Pain Relevance 0.07
This leads to a decrease in the placental steroido-genesis and HCG production necessary for the maintenance of the corpus luteum.
Negative_regulation (decrease) of Gene_expression (production) of HCG in corpus luteum
2) Confidence 0.38 Published 1977 Journal Arch Gynakol Section Abstract Doc Link 577127 Disease Relevance 0.16 Pain Relevance 0.10
After the surgical procedure, the levels of hCG and estradiol rapidly decreased, and the gynecomastia resolved completely within 3 months.
Negative_regulation (decreased) of Gene_expression (levels) of hCG
3) Confidence 0.37 Published 2003 Journal Endocr Pract Section Body Doc Link 12917067 Disease Relevance 0.15 Pain Relevance 0
All of them had depressed hCG, SP1 and PAPP-A levels.
Negative_regulation (depressed) of Gene_expression (levels) of hCG
4) Confidence 0.34 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.50 Pain Relevance 0.06
In the present study, HCG injection on days 2 and 4 after ovulation induction decreased luteal blood flow impedance.
Negative_regulation (decreased) of Gene_expression (injection) of HCG in blood
5) Confidence 0.19 Published 2011 Journal J Ovarian Res Section Body Doc Link PMC3024996 Disease Relevance 0 Pain Relevance 0
Basal gonadotropin levels and gonadotropin responses to acute LHRH stimulation were suppressed within 2 weeks of treatment.
Negative_regulation (suppressed) of Gene_expression (levels) of gonadotropin
6) Confidence 0.19 Published 1983 Journal Lancet Section Abstract Doc Link 6135909 Disease Relevance 0.25 Pain Relevance 0.09
Basal gonadotropin levels and gonadotropin responses to acute LHRH stimulation were suppressed within 2 weeks of treatment.
Negative_regulation (suppressed) of Gene_expression (levels) of gonadotropin
7) Confidence 0.19 Published 1983 Journal Lancet Section Abstract Doc Link 6135909 Disease Relevance 0.25 Pain Relevance 0.09
A neuropeptide named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH2) which directly inhibits gonadotropin synthesis and release from the pituitary was recently identified in quail hypothalamus.
Negative_regulation (inhibits) of Gene_expression (synthesis) of gonadotropin in hypothalamus associated with neuropeptide
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.05
Redistribution of ovarian blood flow after injection of human chorionic gonadotropin and luteinizing hormone in the adult pseudopregnant rat.
Negative_regulation (Redistribution) of Gene_expression (injection) of chorionic gonadotropin in blood
9) Confidence 0.09 Published 1987 Journal Endocrinology Section Title Doc Link 3780557 Disease Relevance 0 Pain Relevance 0.08
In vitro, nitrite was more potent than nitrate in inhibiting human chorionic gonadotropin (hCG)-stimulated androgen synthesis by Mouse Leydig Tumor cells.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of chorionic gonadotropin in Mouse associated with cancer
10) Confidence 0.08 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11133344 Disease Relevance 0.18 Pain Relevance 0.17
Secondary efficacy variables included the percentage of cycles with oocyte retrieval; duration of gonadotropin therapy; total FSH dose; peak serum E2 levels; embryo transfer and implantation rates; chemical pregnancies (positive serum ?
Negative_regulation (duration) of Gene_expression (therapy) of gonadotropin in embryo
11) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0 Pain Relevance 0
Norplant achieves its contraceptive effect by inhibiting the positive feedback exercised by estradiol on the hypothalamus and thus reducing levels of luteinizing hormone and follicle stimulating hormone, by rendering the cervical mucus inhospitable to passage of sperm, and by altering the composition of the endometrial tissue.
Negative_regulation (reducing) of Gene_expression (levels) of luteinizing hormone in sperm
12) Confidence 0.03 Published 1992 Journal Profamilia Section Abstract Doc Link 12286384 Disease Relevance 0.30 Pain Relevance 0.13
Patients with progesterone levels below 10 ng/ml (31.8 nmol/L) and hCG levels below 1,500 mIU/L are more likely to demonstrate spontaneous resolution of EP.32
Negative_regulation (levels) of Gene_expression (levels) of hCG associated with ectopic pregnancy
13) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.88 Pain Relevance 0.08
These drugs cause progesterone withdrawal over a few days, causing detachment of the trophoblast, impaired beta-hCG production, increased sensitivity of the myometrium to PGs and possibly ripening of the cervix.
Negative_regulation (impaired) of Gene_expression (production) of hCG in cervix associated with withdrawal
14) Confidence 0.00 Published 1990 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 2225601 Disease Relevance 0.35 Pain Relevance 0.13

General Comments

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