INT298112
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels
Ca2+/calmodulin- and voltage-dependent inactivation (CDI and VDI) comprise vital prototypes of Ca2+ channel modulation, rich with biological consequences. | |||||||||||||||
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Ga < 0) diminish CDImax (Fig. 1 F, dashed curve) because mutations that enhance opening in the normal gating mode also enhance opening within the inactivated mode. | |||||||||||||||
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Ga < 0) proportionally diminished CDI, in good agreement with the ideal relation for allosteric inhibition (solid curve). | |||||||||||||||
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General Comments
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