INT298112

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.09
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Cd1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 18 91.76 High High
Migraine 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 12 88.60 High High
Channelopathies 24 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Migraine With Aura 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Ataxia 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels

Ca2+/calmodulin- and voltage-dependent inactivation (CDI and VDI) comprise vital prototypes of Ca2+ channel modulation, rich with biological consequences.

Negative_regulation (inactivation) of CDI
1) Confidence 0.42 Published 2010 Journal The Journal of General Physiology Section Title Doc Link PMC2828906 Disease Relevance 0.09 Pain Relevance 0
Ga < 0) diminish CDImax (Fig. 1 F, dashed curve) because mutations that enhance opening in the normal gating mode also enhance opening within the inactivated mode.
Negative_regulation (diminish) of CDI
2) Confidence 0.41 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.04
Ga < 0) proportionally diminished CDI, in good agreement with the ideal relation for allosteric inhibition (solid curve).
Negative_regulation (diminished) of CDI
3) Confidence 0.41 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.05

General Comments

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