INT298112

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.09 Pain Relevance 0.09

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1) lysosome (Cd1d1) cytoplasm (Cd1d1)

Cd1d1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat addiction 18 91.76 Migraine 6 5.00 agonist 3 5.00 sodium channel 3 5.00 antagonist 3 5.00

Disease Link Frequency Relevance Heat Shock 12 88.60 Channelopathies 24 5.00 Syndrome 12 5.00 Disease 9 5.00 Congenital Anomalies 6 5.00 Migraine With Aura 3 5.00 Headache 3 5.00 Ataxia 3 5.00 Autism 3 5.00 Cytomegalovirus Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Cav1.3 channels Ca2+/calmodulin- and voltage-dependent inactivation (CDI and VDI) comprise vital prototypes of Ca2+ channel modulation, rich with biological consequences.

Negative_regulation (inactivation) of CDI

1) Confidence 0.42 Published 2010 Journal The Journal of General Physiology Section Title Doc Link PMC2828906 Disease Relevance 0.09 Pain Relevance 0

Ga < 0) diminish CDImax (Fig. 1 F, dashed curve) because mutations that enhance opening in the normal gating mode also enhance opening within the inactivated mode.

Negative_regulation (diminish) of CDI

2) Confidence 0.41 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.04

Ga < 0) proportionally diminished CDI, in good agreement with the ideal relation for allosteric inhibition (solid curve).

Negative_regulation (diminished) of CDI

3) Confidence 0.41 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.05

General Comments

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