INT29812

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.66
Pain Relevance 14.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ap1m2) vesicle-mediated transport (Ap1m2) Golgi apparatus (Ap1m2)
Anatomy Link Frequency
central nervous system 4
nucleus accumbens 1
cerebrospinal fluid 1
vagus nerve 1
brain 1
Ap1m2 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 60 100.00 Very High Very High Very High
Central nervous system 20 99.84 Very High Very High Very High
opioid receptor 8 99.20 Very High Very High Very High
Enkephalin 33 99.04 Very High Very High Very High
Nucleus accumbens 8 98.76 Very High Very High Very High
vagus nerve 8 98.68 Very High Very High Very High
Limbic system 8 97.98 Very High Very High Very High
analgesia 13 97.54 Very High Very High Very High
Morphine 12 97.14 Very High Very High Very High
Central grey 8 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 16 99.40 Very High Very High Very High
Sprains And Strains 30 99.20 Very High Very High Very High
Pain 11 87.92 High High
Convulsion 2 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differences may relate to previously demonstrated strain differences in the amounts of mu 1 and mu 2 opioid binding in central nervous system areas thought to mediate these behaviors.
mu 2 Binding (binding) of in central nervous system associated with central nervous system, sprains and strains and opioid
1) Confidence 0.33 Published 1985 Journal Brain Res. Section Abstract Doc Link 4084809 Disease Relevance 0.74 Pain Relevance 1.10
Autoradiographic analysis of mu1, mu2, and delta opioid binding in the central nervous system of C57BL/6BY and CXBK (opioid receptor-deficient) mice.
mu2 Binding (binding) of in central nervous system associated with opioid receptor, central nervous system and opioid
2) Confidence 0.14 Published 1985 Journal Brain Res. Section Title Doc Link 3000528 Disease Relevance 0.35 Pain Relevance 0.86
In this study we used semi-quantitative in vitro autoradiography to compare the levels of binding to central mu1, mu2, and delta opioid sites in two strains of mice, C57BL/6BY and CXBK.
mu2 Binding (binding) of associated with sprains and strains and opioid
3) Confidence 0.13 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000528 Disease Relevance 0.28 Pain Relevance 0.86
Binding to mu1 sites was determined by subtracting mu2 binding from total mu binding.
mu2 Binding (binding) of
4) Confidence 0.13 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000528 Disease Relevance 0.42 Pain Relevance 1.00
We have used quantitative in vitro autoradiography to compare the levels of mu1 and mu2 opioid binding in the mouse central nervous system.
mu2 Binding (binding) of in central nervous system associated with central nervous system and opioid
5) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0 Pain Relevance 0.75
This differential regional localization of mu1 and mu2 binding provides further evidence for the distinctness of these sites.
mu2 Binding (binding) of
6) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.24 Pain Relevance 1.04
In other areas, such as the limbic system, dorsal nucleus of the vagus nerve, and nucleus of the solitary tract, either a low ratio of mu1 to mu2 binding or no mu1 binding was observed.
mu2 Binding (binding) of in nucleus associated with vagus nerve and limbic system
7) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.25 Pain Relevance 1.17
Autoradiographic distribution of mu1 and mu2 opioid binding in the mouse central nervous system.
mu2 Binding (binding) of in central nervous system associated with central nervous system and opioid
8) Confidence 0.11 Published 1985 Journal Brain Res. Section Title Doc Link 3000529 Disease Relevance 0.17 Pain Relevance 0.99
Levels of mu1 binding were determined by subtracting mu2 binding from total mu binding.
mu2 Binding (binding) of
9) Confidence 0.09 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.24 Pain Relevance 1.27
High ratios of mu1 to mu2 binding were noted in frontal cortex, nucleus accumbens, rostral striatum, ventral pallidum, ventral periaqueductal gray matter, and laminae I and II of the spinal cord.
mu2 Binding (binding) of in frontal cortex associated with nucleus accumbens, urological neuroanatomy, central grey and spinal cord
10) Confidence 0.08 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.28 Pain Relevance 1.32
In the present study, 8 day treatment with naltrexone blocked morphine and DADLE analgesia for the entire treatment period and increased mu 1, mu 2 and delta opioid receptor binding sites in mouse brain. mu 1 and mu 2 binding were increased by 81 and 67%, respectively, while delta binding was increased by 31%.
mu 2 Binding (binding) of in brain associated with opioid receptor, analgesia and morphine
11) Confidence 0.05 Published 1988 Journal Life Sci. Section Abstract Doc Link 2845219 Disease Relevance 0 Pain Relevance 1.15
At the opioid receptor subtype, laudanosine lowered radiolabeled opioid binding at the mu 1, mu 2, delta, kappa 1, and kappa 3 receptors with Ki values of 2.7, 13, 5.5, 21, and 24 microM, respectively, concentrations seen clinically in blood and approaching those measured in cerebrospinal fluid.
mu 2 Binding (binding) of in cerebrospinal fluid associated with opioid receptor and opioid
12) Confidence 0.04 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069669 Disease Relevance 0.16 Pain Relevance 0.56
In other areas, such as the limbic system, dorsal nucleus of the vagus nerve, and nucleus of the solitary tract, either a low ratio of mu1 to mu2 binding or no mu1 binding was observed.
mu2 Binding (binding) of in vagus nerve associated with vagus nerve and limbic system
13) Confidence 0.04 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.25 Pain Relevance 1.17
High ratios of mu1 to mu2 binding were noted in frontal cortex, nucleus accumbens, rostral striatum, ventral pallidum, ventral periaqueductal gray matter, and laminae I and II of the spinal cord.
mu2 Binding (binding) of in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy, central grey and spinal cord
14) Confidence 0.03 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.28 Pain Relevance 1.32

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