INT29818

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Context Info
Confidence 0.27
First Reported 1988
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.08
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Anatomy Link Frequency
plasma 2
blood 1
nerves 1
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 21 99.72 Very High Very High Very High
Deafferentation 6 99.32 Very High Very High Very High
antidepressant 89 97.60 Very High Very High Very High
fluoxetine 13 89.52 High High
metalloproteinase 12 87.96 High High
Desipramine 8 84.88 Quite High
Endep 2 82.44 Quite High
Hippocampus 4 63.44 Quite High
depression 19 50.00 Quite Low
chemokine 8 14.24 Low Low
Disease Link Frequency Relevance Heat
Toxicity 1 80.80 Quite High
Depression 19 50.00 Quite Low
Dysmenorrhea 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, imipramine had no effect on the PI: myo-inositol exchange enzyme activity.
Neg (no) Regulation (effect) of PI
1) Confidence 0.27 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.28
No significant alteration in the PI synthetase activity was found following either acute (2 h) or chronic (21 d) treatment of rats with imipramine.
Neg (No) Regulation (alteration) of PI
2) Confidence 0.27 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.27
Nitric oxide precursor L-arginine had a normalizing effect on reduced activity of alpha(1)-antitrypsin after capsaicin deafferentation.
Regulation (effect) of antitrypsin associated with qutenza and deafferentation
3) Confidence 0.18 Published 2008 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.62
Regulation of activity of serine proteinase inhibitor a1-antitrypsin and nonspecific proteinase inhibitor alpha(2)-macroglobulin in the blood by nitric oxide was studied in intact rats and animals with damage to capsaicin-sensitive nerves.
Regulation (Regulation) of antitrypsin in blood associated with qutenza
4) Confidence 0.18 Published 2008 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.32
Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves.
Regulation (regulation) of antitrypsin in nerves associated with qutenza
5) Confidence 0.18 Published 2008 Journal Bull. Exp. Biol. Med. Section Title Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.64
The opposite effect was observed for prostromelysin 53 kDa (proMMP3), plasma proteinase I alpha and alpha 1 antiproteinase – all of which were significantly up regulated by PGF2?
Regulation (regulated) of alpha 1 antiproteinase in plasma
6) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.04
First, we tested the effects of the general PI metabolism inhibitor, neomycin, against the maximally effective concentrations of the selected antidepressant agents.
Regulation (effects) of PI associated with antidepressant
7) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.42
The opposite effect was observed for prostromelysin 53 kDa (proMMP3), plasma proteinase I alpha and alpha 1 antiproteinase – all of which were significantly up regulated by PGF2?
Regulation (regulated) of plasma proteinase I alpha in plasma
8) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.04

General Comments

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