INT2982

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.08
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
molar 4
corpus 2
CSF 2
ovaries 2
corpus luteum 2
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 44 100.00 Very High Very High Very High
narcan 6 99.74 Very High Very High Very High
agonist 48 99.62 Very High Very High Very High
Serotonin 10 99.40 Very High Very High Very High
Dismenorea 9 99.28 Very High Very High Very High
Bioavailability 8 96.80 Very High Very High Very High
imagery 1 87.60 High High
Opioid 3 82.00 Quite High
headache 16 76.76 Quite High
pain pelvic 1 75.96 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 143 100.00 Very High Very High Very High
Anovulation 48 100.00 Very High Very High Very High
Dysmenorrhea 3 99.28 Very High Very High Very High
Breast Cancer 2 99.04 Very High Very High Very High
Reprotox - General 2 34 98.48 Very High Very High Very High
Metastasis 8 98.40 Very High Very High Very High
Cicatrix 1 98.28 Very High Very High Very High
Hyperemesis Gravidarum 106 97.60 Very High Very High Very High
Lung Cancer 1 95.60 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 5 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This conclusion is based on observed associations between increased production of HCG (as in molar or in multiple pregnancies) [13-15] and the fact that the incidence of hyperemesis is highest at the time when HCG production reaches its peak during pregnancy (around 9 weeks gestation) [13].
Positive_regulation (increased) of Gene_expression (production) of HCG in molar
1) Confidence 0.59 Published 2010 Journal BMC Med Section Body Doc Link PMC2913953 Disease Relevance 1.22 Pain Relevance 0
Four years after initial therapy, elevated serum HCG levels were detected.
Positive_regulation (elevated) of Gene_expression (levels) of HCG
2) Confidence 0.47 Published 2007 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 17564107 Disease Relevance 1.80 Pain Relevance 0.11
The elevated HCG and AFP levels in serum and CSF returned to their normal range within 2 months after surgery.
Positive_regulation (elevated) of Gene_expression (levels) of HCG in CSF
3) Confidence 0.46 Published 1994 Journal No Shinkei Geka Section Abstract Doc Link 8078594 Disease Relevance 1.01 Pain Relevance 0.05
Use of follitropin alpha in ovulation induction
Positive_regulation (induction) of Gene_expression (Use) of follitropin alpha
4) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.19 Pain Relevance 0.16
Both follitropin alpha and lutropin alpha are manufactured by recombinant DNA technology.12,32 The gene encoded for the bio formation of each hormone is incorporated into a genetically engineered Chinese hamster cell line.20,46 The products of this cell line are then extracted and purified by means of a series of immunochromatograpic techniques.46,47 which help to maintain quality assurance and batch to batch consistency.3,48,49 The current manufacturing process permits the follitropin alpha active ingredient to be quantified by its protein content (mass in ?
Positive_regulation (incorporated) of Gene_expression (manufactured) of follitropin alpha
5) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0.09
Use of follitropin alpha in ovulation induction
Positive_regulation (Use) of Gene_expression (Use) of follitropin alpha
6) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.19 Pain Relevance 0.16
Both follitropin alpha and lutropin alpha are manufactured by recombinant DNA technology.12,32 The gene encoded for the bio formation of each hormone is incorporated into a genetically engineered Chinese hamster cell line.20,46 The products of this cell line are then extracted and purified by means of a series of immunochromatograpic techniques.46,47 which help to maintain quality assurance and batch to batch consistency.3,48,49 The current manufacturing process permits the follitropin alpha active ingredient to be quantified by its protein content (mass in ?
Positive_regulation (incorporated) of Gene_expression (manufactured) of lutropin alpha
7) Confidence 0.43 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0.09
This leads to a decrease in the placental steroido-genesis and HCG production necessary for the maintenance of the corpus luteum.
Positive_regulation (necessary) of Gene_expression (production) of HCG in corpus luteum
8) Confidence 0.41 Published 1977 Journal Arch Gynakol Section Abstract Doc Link 577127 Disease Relevance 0.15 Pain Relevance 0.09
This conclusion is based on observed associations between increased production of HCG (as in molar or in multiple pregnancies) [13-15] and the fact that the incidence of hyperemesis is highest at the time when HCG production reaches its peak during pregnancy (around 9 weeks gestation) [13].
Positive_regulation (reaches) of Gene_expression (production) of HCG in molar
9) Confidence 0.34 Published 2010 Journal BMC Med Section Body Doc Link PMC2913953 Disease Relevance 1.12 Pain Relevance 0
As ovulation induction in women with clomifene-resistant WHO group II anovulation, follitropin alpha produces rates of ovulation, follicular development and pregnancy resembling those seen with urofollitropin or highly purified urofollitropin.
Positive_regulation (induction) of Gene_expression (produces) of follitropin alpha associated with anovulation
10) Confidence 0.31 Published 1998 Journal BioDrugs Section Abstract Doc Link 18020563 Disease Relevance 0.53 Pain Relevance 0.06
The effect of the hGH was dose-dependent and statistically significant at 10 ng/ml, while naloxone was able to increase hCG and progesterone production only at the highest doses (250-500 ng/ml).
Positive_regulation (increase) of Gene_expression (production) of hCG associated with narcan
11) Confidence 0.27 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.45
The relative cost per gonadotropin preparation increases with its purity, but the absolute costs differ between countries.
Positive_regulation (increases) of Gene_expression (preparation) of gonadotropin
12) Confidence 0.05 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.57 Pain Relevance 0.21
In addition, the expression of LH/hCG-R has been demonstrated in endometriosis and has been shown to be increased in patients with adenomyosis [33–35].
Positive_regulation (increased) of Gene_expression (expression) of hCG associated with endometriosis and dismenorea
13) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.74 Pain Relevance 0.15
Also in this case, the highest expression of the LH/hCG-R occurred during the luteal phase of the cycle, and paralleled an increased synthesis of PGE2.
Positive_regulation (occurred) of Gene_expression (expression) of hCG
14) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.05 Pain Relevance 0
This enhanced expression of luteal Cu-Zn SOD may be due to hCG and hCG may have an important role in maintenance of corpus luteal function in pregnancy.
Positive_regulation (enhanced) of Gene_expression (expression) of hCG in corpus
15) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.23 Pain Relevance 0
Increased Luteinizing Hormone (LH) levels, compared to the FSH, result in increased androgen production in the ovaries.
Positive_regulation (Increased) of Gene_expression (levels) of Luteinizing Hormone in ovaries
16) Confidence 0.03 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.28 Pain Relevance 0
We found that: (i) the blockade of the serotoninergic system after PCPA administration did not modify basal gonadotropin secretion but did strongly reduce the response to orchidectomy; (ii) a stimulatory effect of 5-HTP on FSH secretion was only observed in intact males at the age of 8 days; (iii) the serotonin 1A agonist 8-OH-DPAT did not change serum gonadotropin concentrations; (iv) 5-HTP increased serum FSH and LH concentrations in 16-day-old castrated males; (v) FSH and LH serum concentrations decreased after 5-HTP in castrated animals implanted with testosterone, whereas castrated animals implanted with alpha-diol showed, like the intact males, a lack of response to 5-HTP.
Positive_regulation (change) of Gene_expression (concentrations) of serum gonadotropin associated with agonist and serotonin
17) Confidence 0.01 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8205265 Disease Relevance 0 Pain Relevance 0.38

General Comments

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