INT298203

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (MPHOSPH6) RNA binding (MPHOSPH6) nucleus (MPHOSPH6)
cytoplasm (MPHOSPH6)
MPHOSPH6 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 76.96 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 90 97.04 Very High Very High Very High
Cancer 12 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 8 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Non-small-cell Lung Cancer 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous EGF trigged a further increase in ERK and AKT phosphorylation in MPP89 and AKT phosphorylation in Ist-Mes-1, indicating that the EGF-EGFR pathway was activated in these cell lines.
Phosphorylation (phosphorylation) of MPP89
1) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.15 Pain Relevance 0.04
To determine the effect of gefitinib on the phosphorylation status of EGFR, Ist-Mes-1, Ist-Mes-2 and MPP89, cells were seeded in T25 flask in full culture media for 24 h. 45 mins after the addition of gefitinib, EGF (final concentration 100 ng/ml) was added.
Phosphorylation (phosphorylation) of MPP89
2) Confidence 0.00 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.10 Pain Relevance 0

General Comments

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