INT29821

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 2.98
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Anatomy Link Frequency
brain 2
Liver 1
apoptotic cell 1
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 1082 99.56 Very High Very High Very High
agonist 143 99.50 Very High Very High Very High
monoamine 169 98.80 Very High Very High Very High
fluoxetine 144 98.48 Very High Very High Very High
Desipramine 79 98.24 Very High Very High Very High
depression 247 96.48 Very High Very High Very High
sSRI 104 96.40 Very High Very High Very High
opiate 3 92.68 High High
Potency 13 89.80 High High
Kinase C 52 84.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 36 100.00 Very High Very High Very High
Necrosis 8 99.72 Very High Very High Very High
Death 10 99.40 Very High Very High Very High
Gallstones 2 98.90 Very High Very High Very High
Depression 247 96.48 Very High Very High Very High
Urological Neuroanatomy 26 96.00 Very High Very High Very High
Toxicity 13 95.88 Very High Very High Very High
Hepatitis Virus Infection 2 95.60 Very High Very High Very High
Hepatitis C Virus Infection 2 94.84 High High
Opiate Addiction 2 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The above results indicate that the de novo synthesis of PI is inhibited in vitro but not ex vivo by some antidepressant drugs.
Gene_expression (synthesis) of PI associated with antidepressant
1) Confidence 0.60 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.26
As we hypothesized that cycloheximide would reduce only the apoptotic cell death by inhibiting active protein synthesis (7), our data of simultaneous inhibition of both apoptosis (annexin V+/PI-) and necrosis (annexin V+/PI+) with cycloheximide treatment observed by flow cytometry in the present study were rather unexpected.
Gene_expression (synthesis) of PI in apoptotic cell associated with necrosis, apoptosis and death
2) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2734015 Disease Relevance 1.24 Pain Relevance 0.04
The parameters of Num, Max and Area in the PI + ACRS group were all significantly higher than those of the PI group [Max: (41 +/- 17) mm Hg vs (22 +/- 6) mm Hg, P = 0.000; Area: (7693 +/- 2822) mm Hg.s vs (5092 +/- 1687) mm Hgxs, P = 0.000; Num: 9.5 +/- 2.6 vs 6.6 +/- 3.1, P = 0.000]; so was the distension volume of AWR3 [(2.25 +/- 0.29) ml vs (2.52 +/- 0.32) ml, P = 0.004].
Gene_expression (those) of PI
3) Confidence 0.18 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137711 Disease Relevance 0 Pain Relevance 0
The parameters of Num, Max and Area in the PI + ACRS group were all significantly higher than those of the PI group [Max: (41 +/- 17) mm Hg vs (22 +/- 6) mm Hg, P = 0.000; Area: (7693 +/- 2822) mm Hg.s vs (5092 +/- 1687) mm Hgxs, P = 0.000; Num: 9.5 +/- 2.6 vs 6.6 +/- 3.1, P = 0.000]; so was the distension volume of AWR3 [(2.25 +/- 0.29) ml vs (2.52 +/- 0.32) ml, P = 0.004].
Gene_expression (group) of PI
4) Confidence 0.18 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137711 Disease Relevance 0 Pain Relevance 0
Antidepressant-induced CDP-diacylglycerol formation translates into increased PI synthesis
Gene_expression (synthesis) of PI associated with antidepressant
5) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.72
Neomycin concentration-dependently blocked the effects of imipramine, desipramine, fluoxetine, paroxetine, maprotiline, or nomifensine on CDP-DG production (Figure 5A), PI resynthesis (Figure 5B) or IP accumulation (data not shown) in hippocampal or prefrontal cortical brain slices.
Gene_expression (resynthesis) of PI in brain associated with desipramine and fluoxetine
6) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.07 Pain Relevance 0.36
Effects of monoamine oxidase inhibiting agents CDP-diacylglycerol formation and PI synthesis
Gene_expression (synthesis) of PI associated with monoamine
7) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.52
Hence, to the extent that CDP-DG production might be relevant to depression or the mechanism of antidepressant drug action, an antidepressive agent should not merely increase PI hydrolysis, but the CDP-DG produced must exceed and probably precede the production of PI messengers.
Gene_expression (production) of PI associated with antidepressant and depression
8) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.74
How then might an effect of antidepressant agents on CDP-DG and PI synthesis be associated with the antidepressive efficacy of the compounds?
Gene_expression (synthesis) of PI associated with antidepressant
9) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.38
To measure the levels of IPs formed, tissues were treated exactly as in the foregoing PI synthesis assays, including the use of [3H]inositol for prelabeling of the PI pool.
Gene_expression (synthesis) of PI
10) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0
Carbachol failed to increase PI synthesis, SKF38393 significantly enhanced PI synthesis, while the other two agents had significant but relatively small effects on PI.
Gene_expression (synthesis) of PI
11) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.29
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Gene_expression (resynthesis) of PI
12) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.07 Pain Relevance 0.23
Antidepressant-induced CDP-diacylglycerol formation partially depends on PI hydrolysis
Gene_expression (hydrolysis) of PI associated with antidepressant
13) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.41
To validate the effects of U73122, we also tested the compound against the action of SKF38393, a D1 receptor agonist that is known to induce PI hydrolysis in these brain tissues [14,65].
Gene_expression (hydrolysis) of PI in brain associated with agonist
14) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.50
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Gene_expression (resynthesis) of PI
15) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.22
Liver functional tests, cholestasis development and serum acute phase proteins, including a-1-proteinase inhibitor (PI) and albumin level (negative reactant of acute phase proteins), C-reactive protein (CRP) have been studied in the patients with viral hepatitis C (HCV) and/or drug addictive disorders (crude home-made opiates).
Gene_expression (level) of a-1-proteinase inhibitor in Liver associated with hepatitis virus infection, opiate, hepatitis c virus infection and gallstones
16) Confidence 0.08 Published 2007 Journal Alaska Med Section Abstract Doc Link 17929611 Disease Relevance 0.67 Pain Relevance 0.32
Following our previously reported preliminary observations [64], we have now examined antidepressant drug effects on cellular diacylglycerol production and metabolism, including the resynthesis of the PI substrates.
Gene_expression (resynthesis) of PI associated with antidepressant
17) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.12 Pain Relevance 0.34
This implies that the compounds do not inhibit IP breakdown (otherwise they would have substituted for Li+), and that their effects on IP accumulation is probably secondary and passive to the enhanced production of upstream CDP-DG and PI substrates.
Gene_expression (production) of PI
18) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.40

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