INT298236

Context Info Confidence 0.51 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0

cell differentiation (Hes5) cell adhesion (Hes5) nucleus (Hes5) protein complex assembly (Hes5) DNA binding (Hes5) transcription factor binding (Hes5)

Hes5 (Mus musculus)

Pain Link Frequency Relevance Heat trigeminal ganglion 75 50.00 nociceptor 32 5.00 calcitonin gene related peptide 11 5.00 Neuropeptide 4 5.00 mu opioid receptor 4 5.00 substance P 3 5.00 Somatostatin 3 5.00 Central nervous system 2 5.00 Spinal cord 2 5.00 Serotonin 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 43 89.08 Repression 7 82.64 Ganglion Cysts 85 50.00 Pain 3 5.00 Nociception 3 5.00 Neurodegenerative Disease 3 5.00 Death 2 5.00 Herpes Simplex Virus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Two of the most prominent transcripts in this category are Hes5 and Runx3, and Runx3 was selected for further studies of direct regulation by Brn3a.

Localization (selected) of Hes5

1) Confidence 0.51 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.