INT298245

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.03

nucleus (Irx2) DNA binding (Irx2)

Irx2 (Mus musculus)

Pain Link Frequency Relevance Heat trigeminal ganglion 75 64.04 Spinal cord 2 10.24 superficial lamina 1 9.48 nociceptor 32 5.00 calcitonin gene related peptide 11 5.00 Neuropeptide 4 5.00 mu opioid receptor 4 5.00 substance P 3 5.00 Somatostatin 3 5.00 Central nervous system 2 5.00

Disease Link Frequency Relevance Heat Repression 7 99.50 Targeted Disruption 43 94.72 Ganglion Cysts 85 64.04 Pain 3 5.00 Nociception 3 5.00 Neurodegenerative Disease 3 5.00 Death 2 5.00 Herpes Simplex Virus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other potential targets of direct repression revealed by this screen include Neurog1 (neurogenin 1) and the homeodomain factor Irx2.

Negative_regulation (include) of Irx2 associated with repression

1) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

This test has worked.