INT298246

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.81
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 2
ganglia 1
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 450 100.00 Very High Very High Very High
calcitonin gene related peptide 66 99.12 Very High Very High Very High
Glutamate 12 96.48 Very High Very High Very High
nociceptor 192 93.28 High High
Acute pain 6 90.44 High High
Endep 4 89.24 High High
Serotonin 12 79.60 Quite High
tricyclic antidepressant 4 75.04 Quite High
Neuropeptide 24 44.40 Quite Low
Somatostatin 18 38.44 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 526 100.00 Very High Very High Very High
Targeted Disruption 278 99.96 Very High Very High Very High
Apoptosis 32 95.56 Very High Very High Very High
Pain 22 90.44 High High
Repression 42 90.24 High High
Nociception 18 86.68 High High
Neurodegenerative Disease 24 84.08 Quite High
Anxiety Disorder 46 5.00 Very Low Very Low Very Low
Death 20 5.00 Very Low Very Low Very Low
Shock 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Positive_regulation (maintenance) of TrkC
1) Confidence 0.48 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.77 Pain Relevance 0.56
However, ectopic expression of Runx1 in E12.5 DRG represses TrkB expression, promotes both TrkA and TrkC, and appears to be interchangeable with Runx3 in these effects [23].
Positive_regulation (promotes) of TrkC
2) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.34 Pain Relevance 0.39
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Positive_regulation (populations) of TrkC in ganglia
3) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
TrkC is widely expressed in the TG at E10.5, and overlaps TrkB at this stage (Figure 4A).
Positive_regulation (overlaps) of TrkC associated with trigeminal ganglion
4) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.57 Pain Relevance 0.47
In control TG, Runx3 expression follows TrkC by one developmental day.
Positive_regulation (follows) of TrkC associated with trigeminal ganglion
5) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.63 Pain Relevance 0.47
No significant late appearance of TrkC-expressing neurons was observed in the Brn3a-/- TG, and the rare TrkC neurons observed at P0 are Runx3+, and have large soma characteristic of proprioceptors or mechanoreceptors (Figure 2B).
Neg (No) Positive_regulation (appearance) of TrkC in neurons associated with trigeminal ganglion
6) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.51 Pain Relevance 0.41
Noticeably, the spontaneous caspase-3 activation in TrkC ?
Positive_regulation (activation) of TrkC
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.39 Pain Relevance 0.29
Moreover, deoxygedunin strongly provoked TrkB but not TrkA activation in both wild-type and TrkC knockout neurons (Figure 4B, top panel).
Neg (not) Positive_regulation (activation) of TrkC in neurons associated with targeted disruption
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.39 Pain Relevance 0.30

General Comments

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