INT298248

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mrgpra1) plasma membrane (Mrgpra1) cellular_component (Mrgpra1)
signal transducer activity (Mrgpra1)
Mrgpra1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 150 99.18 Very High Very High Very High
calcitonin gene related peptide 22 99.00 Very High Very High Very High
Neuropeptide 8 94.64 High High
substance P 6 92.80 High High
nociceptor 64 89.12 High High
mu opioid receptor 8 82.36 Quite High
Somatostatin 6 79.68 Quite High
Nav1.9 2 79.04 Quite High
nav1.8 2 78.32 Quite High
tetrodotoxin-resistant sodium channels 2 77.76 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 170 99.18 Very High Very High Very High
Targeted Disruption 86 77.36 Quite High
Pain 6 68.16 Quite High
Nociception 6 51.04 Quite High
Repression 14 16.00 Low Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TG of Brn3a-/- newborn mice exhibit marked reduction in Trpm8, Mrga1, Mrgd and Scn11a, while CGRP and SP are minimally affected.
Negative_regulation (reduction) of Mrga1 associated with calcitonin gene related peptide and trigeminal ganglion
1) Confidence 0.33 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.49 Pain Relevance 0.88
Expression of TrpM8 was undetectable, and Mrgprd, Mrgpra1, and Scn11a were markedly reduced.
Negative_regulation (reduced) of Mrgpra1
2) Confidence 0.29 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 1.02

General Comments

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