INT298250

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.92
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 2
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 300 99.58 Very High Very High Very High
nociceptor 128 97.16 Very High Very High Very High
calcitonin gene related peptide 44 84.36 Quite High
Neuropeptide 16 75.68 Quite High
mu opioid receptor 16 21.36 Low Low
substance P 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 172 99.88 Very High Very High Very High
Ganglion Cysts 340 99.58 Very High Very High Very High
Nociception 12 83.04 Quite High
Repression 28 75.48 Quite High
Death 8 73.48 Quite High
Pain 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Brn3a-/- TG exhibits a profound decrease in the expression of both Runx3 and Runx1, and failure to appropriately activate Runx expression can account for much of the early developmental phenotype of the Brn3a-/- TG.
Negative_regulation (decrease) of Gene_expression (expression) of Runx3 associated with trigeminal ganglion
1) Confidence 0.56 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.43
Consistent with prior observations [11,18], we observed an almost complete loss of TrkC in the Brn3a knockout, and Runx3 expression was also nearly absent (Figure 2B).
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of Runx3 associated with targeted disruption
2) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.91 Pain Relevance 0.20
E13.5 was chosen for these assays, 1 to 2 days after the initiation of Runx3 expression, because we reasoned that at this time point regulators of Runx3 expression would still be bound to their targets.
Negative_regulation (initiation) of Gene_expression (expression) of Runx3
3) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.08
This suggests that Runx1 promotes TrkC expression in late-developing cutaneous neurons in Runx3 knockouts, but not in Brn3a-/- ganglia in which both Runx1 and Runx3 expression are severely attenuated.


Negative_regulation (attenuated) of Gene_expression (expression) of Runx3 in neurons
4) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.37 Pain Relevance 0.74

General Comments

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