INT298253

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3) DNA binding (Runx3) cytoplasm (Runx3)
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 225 95.64 Very High Very High Very High
nociceptor 96 94.68 High High
Acute pain 3 91.84 High High
Serotonin 6 81.00 Quite High
Somatostatin 9 39.84 Quite Low
substance P 9 28.68 Quite Low
calcitonin gene related peptide 33 28.04 Quite Low
Neuropeptide 12 27.84 Quite Low
mu opioid receptor 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 255 95.64 Very High Very High Very High
Pain 9 91.84 High High
Targeted Disruption 129 91.40 High High
Nociception 9 88.08 High High
Repression 21 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E13.5 was chosen for these assays, 1 to 2 days after the initiation of Runx3 expression, because we reasoned that at this time point regulators of Runx3 expression would still be bound to their targets.
Regulation (regulators) of Gene_expression (expression) of Runx3
1) Confidence 0.59 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.15 Pain Relevance 0.08
Together these data suggest that permitting the initiation of Runx3 expression is one of the primary roles of Brn3a.
Regulation (initiation) of Gene_expression (expression) of Runx3
2) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.28 Pain Relevance 0.15
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Regulation (initiation) of Gene_expression (expression) of Runx3
3) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.78 Pain Relevance 0.62

General Comments

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