INT298256

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) nucleus (Runx1)
DNA binding (Runx1) kinase activity (Ntrk1) transcription factor binding (Runx1)
Runx1 (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 87.72 High High
nociceptor 32 50.48 Quite High
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 7 100.00 Very High Very High Very High
Ganglion Cysts 85 87.72 High High
Targeted Disruption 43 84.32 Quite High
Neurodegenerative Disease 3 40.64 Quite Low
Herpes Simplex Virus 1 13.20 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the timing of the onset of Runx1 expression and of TrkA/B discrimination, as well as the loss of Runx1 and TrkA/B discrimination in Brn3a knockouts, are consistent with a role for Runx1 in the repression of TrkB in TrkA/B precursors.
Runx1 Positive_regulation (role) of Negative_regulation (repression) of TrkA associated with repression
1) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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