INT298260

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.08
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx3, Pou4f1) DNA binding (Runx3, Pou4f1) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 1
Runx3 (Mus musculus)
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 525 98.72 Very High Very High Very High
nociceptor 224 85.08 High High
Neuropeptide 28 83.96 Quite High
mu opioid receptor 28 45.48 Quite Low
calcitonin gene related peptide 77 41.40 Quite Low
Central nervous system 14 33.88 Quite Low
substance P 21 5.00 Very Low Very Low Very Low
Somatostatin 21 5.00 Very Low Very Low Very Low
Spinal cord 14 5.00 Very Low Very Low Very Low
Serotonin 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 595 98.72 Very High Very High Very High
Targeted Disruption 301 92.12 High High
Repression 49 55.60 Quite High
Neurodegenerative Disease 21 21.24 Low Low
Pain 21 5.00 Very Low Very Low Very Low
Nociception 21 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chromatin immunoprecipitation demonstrates that Brn3a interacts with a Runx3 upstream enhancer in vivo, revealing the first direct positively regulated Brn3a target.
Runx3 Binding (interacts) of Brn3a
1) Confidence 0.52 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.44 Pain Relevance 0.32
ChIP assays provide less consistent evidence for Brn3a binding to two other regions of the Runx3 locus, and other sites may exist that were not predicted by the consensus recognition sequence used and thus were not tested in this study.


Runx3 Binding (binding) of Brn3a
2) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.17 Pain Relevance 0.06
Chromatin immunoprecipitation demonstrates that Brn3a interacts with a Runx3 upstream enhancer in vivo, revealing the first direct positively regulated Brn3a target.
Runx3 Binding (interacts) of Brn3a
3) Confidence 0.39 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.44 Pain Relevance 0.32
Chromatin immunoprecipitation confirms that Brn3a binds in vivo to a conserved upstream enhancer element within histone H3-acetylated chromatin in the Runx3 locus.
Runx3 Binding (binds) of Brn3a
4) Confidence 0.39 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.49 Pain Relevance 0.30
Here we have shown that Brn3a interacts directly in vivo with an enhancer element located approximately 94 kb upstream of the Runx3 transcriptional start site.
Runx3 Binding (interacts) of Brn3a
5) Confidence 0.39 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.38 Pain Relevance 0.15
Although Brn3a binds directly to a Runx3 enhancer element, it is clear that this is a necessary but not sufficient condition for the initiation of Runx3 expression since Brn3a is widely expressed at the onset of Runx3 expression, yet Runx3 is only initiated in a subset of Brn3a neurons.
Runx3 Spec (clear) Binding (binds) of Brn3a in neurons
6) Confidence 0.39 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0 Pain Relevance 0
Because we have previously shown that in vitro binding of Brn3a to a specific regulatory element is a necessary but not sufficient requirement for in vivo site occupancy [14], we next used ChIP to assay Brn3a binding to its Runx3 locus recognition sites in the TG.
Runx3 Binding (binding) of Brn3a associated with trigeminal ganglion
7) Confidence 0.34 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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