INT298267

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tcf3, Runx1) DNA binding (Tcf3, Runx1) transcription factor binding (Tcf3, Runx1)
cell differentiation (Tcf3) protein complex (Tcf3) cytoplasm (Tcf3)
Anatomy Link Frequency
neurons 2
Tcf3 (Mus musculus)
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 79.52 Quite High
nociceptor 32 42.28 Quite Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 43 100.00 Very High Very High Very High
Repression 7 93.08 High High
Ganglion Cysts 85 79.52 Quite High
Neurodegenerative Disease 3 57.52 Quite High
Herpes Simplex Virus 1 30.08 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further support for a role of Runx1 in restricting the expression of TrkB is derived from the observation that a small number of neurons that maintain Runx1 expression in the Brn3a knockout at E12.5 and E13.5 are TrkB negative (Figure 5D, H).
E12 Positive_regulation (maintain) of Gene_expression (expression) of Runx1 in neurons associated with targeted disruption
1) Confidence 0.21 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.10

General Comments

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