INT298272

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) nucleus (Runx1)
DNA binding (Runx1) kinase activity (Ntrk3) transcription factor binding (Runx1)
Anatomy Link Frequency
neurons 2
nociceptors 2
Runx1 (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 64 99.84 Very High Very High Very High
trigeminal ganglion 150 94.96 High High
calcitonin gene related peptide 22 89.96 High High
Neuropeptide 8 63.68 Quite High
mu opioid receptor 8 9.36 Low Low
substance P 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 170 94.96 High High
Repression 14 81.08 Quite High
Nociception 6 71.04 Quite High
Targeted Disruption 86 52.00 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that Runx1 promotes TrkC expression in late-developing cutaneous neurons in Runx3 knockouts, but not in Brn3a-/- ganglia in which both Runx1 and Runx3 expression are severely attenuated.


Runx1 Positive_regulation (promotes) of Gene_expression (expression) of TrkC in neurons
1) Confidence 0.52 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.66
Thus, it is likely that both Runx1 and Runx3 function to repress TrkB and promote the exclusive expression of TrkA and TrkC in nociceptors and proprioceptors, respectively.
Runx1 Positive_regulation (promote) of Gene_expression (expression) of TrkC in nociceptors associated with nociceptor
2) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.43

General Comments

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