INT298273

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
neurons 1
Pou4f1 (Mus musculus)
target gene site (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 98.52 Very High Very High Very High
Spinal cord 2 66.80 Quite High
superficial lamina 1 66.04 Quite High
nociceptor 32 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
mu opioid receptor 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 85 98.52 Very High Very High Very High
Targeted Disruption 43 93.04 High High
Herpes Simplex Virus 1 9.24 Low Low
Repression 7 7.12 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of VP16 misexpression may be limited because the transgene was not expressed in all TG neurons, and because the VP16-Brn3a protein must compete with endogenous Brn3a for target gene site occupancy.
Brn3a Binding (occupancy) of target gene site in neurons associated with trigeminal ganglion
1) Confidence 0.01 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.53 Pain Relevance 0.18

General Comments

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