INT298279

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.31
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1, Runx3) DNA binding (Pou4f1, Runx3) cytoplasm (Runx3)
Anatomy Link Frequency
neurons 2
ganglia 2
Pou4f1 (Mus musculus)
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 225 99.20 Very High Very High Very High
nociceptor 96 95.72 Very High Very High Very High
Acute pain 3 92.88 High High
Serotonin 6 82.04 Quite High
Neurotransmitter 3 78.32 Quite High
calcitonin gene related peptide 33 42.72 Quite Low
Somatostatin 9 40.88 Quite Low
substance P 9 29.72 Quite Low
Neuropeptide 12 28.88 Quite Low
mu opioid receptor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 255 99.20 Very High Very High Very High
Targeted Disruption 129 97.04 Very High Very High Very High
Pain 9 92.88 High High
Nociception 9 89.12 High High
Repression 21 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a is required for the initiation of Runx3 expression and maintenance of TrkC
Brn3a Positive_regulation (required) of Gene_expression (expression) of Runx3
1) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.79 Pain Relevance 0.63
Brn3a creates a permissive condition for subtype specification by promoting Runx1 and Runx3 expression, which then refine sensory neuron phenotypes by repressing TrkB in prospective TrkA- and TrkC-expressing neurons, respectively.
Brn3a Positive_regulation (promoting) of Gene_expression (expression) of Runx3 in neurons
2) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0 Pain Relevance 0
Here we show that Brn3a also plays a role in sensory subtype specification by promoting the expression of Runx1 and Runx3 in E11.5 to E13.5 ganglia.
Brn3a Positive_regulation (promoting) of Gene_expression (expression) of Runx3 in ganglia
3) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.52 Pain Relevance 0.18

General Comments

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