INT298283

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.40
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1, Runx1) DNA binding (Pou4f1, Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptor 4
sensory neurons 2
Pou4f1 (Mus musculus)
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 225 100.00 Very High Very High Very High
nociceptor 96 99.96 Very High Very High Very High
substance P 9 92.96 High High
calcitonin gene related peptide 33 91.92 High High
Somatostatin 9 88.48 High High
Pain 6 82.80 Quite High
opioid receptor 3 76.40 Quite High
tetrodotoxin-resistant sodium channels 3 66.32 Quite High
nav1.8 3 62.64 Quite High
Nav1.9 3 61.20 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 255 100.00 Very High Very High Very High
Repression 21 91.68 High High
Pain 9 82.80 Quite High
Targeted Disruption 129 74.56 Quite High
Nociception 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a is required for Runx1 expression and the segregation of TrkA/TrkB expression in nociceptor precursors
Brn3a Positive_regulation (required) of Gene_expression (expression) of Runx1 in nociceptor associated with nociceptor
1) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.24
Brn3a is required for the expression of a battery of Runx1-dependent nociceptor markers
Brn3a Positive_regulation (required) of Gene_expression (expression) of Runx1-dependent in nociceptor associated with nociceptor
2) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.94
Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis.

Brn3a Positive_regulation (promoting) of Gene_expression (expression) of Runx in sensory neurons associated with ganglion cysts and trigeminal ganglion
3) Confidence 0.43 Published 2010 Journal Neural Dev Section Title Doc Link PMC2829025 Disease Relevance 0.56 Pain Relevance 0.30

General Comments

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